A novel peptide interferes with Mycobacterium tuberculosis virulence and survival

被引：2

作者：

Samuchiwal, Sachin Kumar ^{[1
]}

Tousif, Sultan ^{[2
,3
,5
]}

Singh, Dhiraj Kumar ^{[2
]}

Kumar, Arun ^{[2
]}

Ghosh, Anamika ^{[1
]}

Bhalla, Kuhulika ^{[1
]}

Prakash, Prem ^{[1
]}

Kumar, Sushil ^{[1
]}

Trivedi, Ashish Chandra ^{[4
]}

Bhattacharyya, Maitree ^{[3
]}

Das, Gobardhan ^{[5
]}

Ranganathan, Anand ^{[1
]}

机构：

[1] ICGEB, Recombinant Gene Prod Grp, Int Ctr Genet Engn & Biotechnol, New Delhi 110067, India

[2] ICGEB, Immunol Grp, Int Ctr Genet Engn & Biotechnol, New Delhi 110067, India

[3] Univ Calcutta, Dept Biochem, Kolkata 700019, India

[4] IMT Manesar, Innovat Life Discoveries Pvt Ltd, Manesar, Haryana, India

[5] Univ Kwazulu Natal, Sch Lab Med, Coll Hlth Sci, Durban, South Africa

来源：

FEBS OPEN BIO | 2014年 / 4卷

关键词：

Antimycobacterial peptides; ESAT6; Mycobacterium tuberculosis; Protein-protein interaction; ESAT-6-CFP-10; COMPLEX; ESAT-6; PROTEINS; PATHOGENESIS; GROWTH; CFP-10; BIND; BCG;

D O I：

10.1016/j.fob.2014.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates. Here, we report that SL3, a novel 33-amino acid peptide, causes debilitating effects on mycobacterial morphology. Treatment with SL3 drastically inhibits the growth of Mycobacterium tuberculosis in vitro as well as in a pre-clinical mouse model for M.tb infection. Microarray analysis of SL3-expressing strain demonstrates wide-scale transcriptional disruption in M.tb. We therefore believe that SL3 and similar peptides may herald a new approach towards discovering new molecules for TB therapy. (C) 2014 The Authors. Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：735 / 740

页数：6

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