Recent progress in understanding the mechanisms of Leydig cell differentiation

被引：16

作者：

Inoue, Miki ^{[1
]}

Baba, Takashi ^{[1
,2
]}

Morohashi, Ken-ichirou ^{[1
,2
]}

机构：

[1] Kyushu Univ, Grad Sch Syst Life Sci, Div Mol Life Sci, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Mol Biol, Higashi Ku, Maidashi 3-1-1, Fukuoka, Fukuoka 8128582, Japan

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2018年 / 468卷

关键词：

Leydig cell; Genome-wide analysis; Reprogramming; EMBRYONIC STEM-CELLS; STEROIDOGENIC FACTOR-I; GENOME-WIDE ANALYSIS; SERTOLI-CELLS; PROGENITOR CELLS; RAT TESTIS; 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE-1; MORPHOMETRIC-ANALYSIS; ENZYME EXPRESSION; GENE-EXPRESSION;

D O I：

10.1016/j.mce.2017.12.013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Leydig cells in fetal and adult testes play pivotal roles in eliciting male characteristics by producing androgen. Although numerous studies of Leydig cells have been performed, the mechanisms for differentiation of the two cell types (fetal Leydig and adult Leydig cells), their developmental and functional relationship, and their differential characteristics remain largely unclear. Based on recent technical progress in genome-wide analysis and in vitro investigation, novel and fascinating observations concerning the issues above have been obtained. Focusing on fetal and adult Leydig cells, this review summarizes the recent progress that has advanced our understanding of the cells. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：39 / 46

页数：8

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