Glutathione and pH serial responsive functional mesoporous silica nanoparticles for drug delivery

被引：1
|
作者：
He, Liang [1 ,2 ]
Nan, Xueyan [1 ]
Wang, Tong [1 ]
Bai, Pengli [1 ,3 ,4 ]
机构：
[1] Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China
[2] Qingdao Univ, Coll Chem & Chem Engn, Inst Biomed Mat & Engn, Qingdao 266071, Peoples R China
[3] Univ Sci & Technol China, Hefei 230026, Peoples R China
[4] Tianjin Guokeyigong Sci & Technol Dev Co Ltd, Tianjin 300399, Peoples R China
来源：
MICRO & NANO LETTERS | 2020年 / 15卷 / 05期
关键词：
CHITOSAN NANOPARTICLES; GRAPHENE OXIDE; CARBON DOTS; CO-DELIVERY; CANCER; NANOCARRIERS; DOXORUBICIN; THERAPY;
D O I：
10.1049/mnl.2019.0317
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
In this work, a novel glutathione and pH serial dual-responsive drug delivery system has been developed, which was constructed with chitosan (CS), carbon dots (CDs) and hyaluronic acid (HA) modified the mesoporous silica nanoparticles (MSNs). The system showed excellent drug loading efficiency, controlled release and targeted delivery. In addition, the platform (MSN-CS@HA-CDs) exhibited fluorescence imaging property. The prepared drug delivery system appeared to be a promising cancer treatment platform.
引用
收藏
页码：291 / 295
页数：5
相关论文
共 50 条
  • [31] pH-responsive drug release from positively charged mesoporous silica nanoparticles and their potential for anticancer drug delivery
    Hemalatha Kanniyappan
    Joseph Jose
    Sudip Chakraborty
    Megala Ramasamy
    Vignesh Muthuvijayan
    Journal of the Australian Ceramic Society, 2023, 59 : 207 - 220
  • [32] pH and reduction sensitive mesoporous silica nanoparticles for targeted drug delivery
    Chen, Liang
    Nie, Wei
    Wang, Weizhong
    Du, Haibo
    Tao, Ling
    Liu, Dinghua
    He, Chuanglong
    JOURNAL OF CONTROLLED RELEASE, 2017, 259 : E79 - E80
  • [33] Glutathione-responsive mesoporous silica nanocarriers with cyclodextrin gatekeepers for drug delivery application
    Lee, Jeonghun
    Hong, Eunjung
    Lee, Hyemi
    Park, Heon Joo
    Kim, Chulhee
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 246
  • [34] Glutathione-sensitive hollow mesoporous silica nanoparticles for controlled drug delivery
    Moghaddam, Seyyed Pouya Hadipour
    Yazdimamaghani, Mostafa
    Ghandehari, Hamidreza
    JOURNAL OF CONTROLLED RELEASE, 2018, 282 : 62 - 75
  • [35] Glutathione-responsive mesoporous silica nanocontainers with cyclodextrin gatekeepers for drug delivery application
    Lee, Jeonghun
    Kim, Min Ji
    Kim, Hyehyeon
    Lee, Hyemi
    Park, Heon Joo
    Kim, Chulhee
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2012, 243
  • [36] pH-Responsive hydroxyapatite and hyaluronic acid modified mesoporous silica nanoparticles for targeted anticancer drug delivery
    Zhang, Qianqian
    Chen, Liang
    Qin, Ming
    Feng, Wei
    Zhou, Xiaojun
    He, Chuanglong
    JOURNAL OF CONTROLLED RELEASE, 2017, 259 : E108 - E109
  • [37] pH and Ultrasound Dual-Responsive Polydopamine-Coated Mesoporous Silica Nanoparticles for Controlled Drug Delivery
    Li, Xiaochong
    Xie, Chuan
    Xia, Hesheng
    Wang, Zhanhua
    LANGMUIR, 2018, 34 (34) : 9974 - 9981
  • [38] Intracellular pH-responsive and rituximabconjugated mesoporous silica nanoparticles for targeted drug delivery to lymphoma B cells
    Zhou, Shoubing
    Wu, Dan
    Yin, Xiaodong
    Jin, Xiaoxiao
    Zhang, Xiu
    Zheng, Shiya
    Wang, Cailian
    Liu, Yanwen
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2017, 36 : 1 - 14
  • [39] Esterase- and pH-responsive poly(β-amino ester)-capped mesoporous silica nanoparticles for drug delivery
    Fernando, Isurika R.
    Ferris, Daniel P.
    Frasconi, Marco
    Malin, Dmitry
    Strekalova, Elena
    Yilmaz, M. Deniz
    Ambrogio, Michael W.
    Algaradah, Mohammed M.
    Hong, Michael P.
    Chen, Xinqi
    Nassar, Majed S.
    Botros, Youssry Y.
    Cryns, Vincent L.
    Stoddart, J. Fraser
    NANOSCALE, 2015, 7 (16) : 7178 - 7183
  • [40] Magnetic targeting and pH-microwave dual responsive Janus mesoporous silica nanoparticles for drug encapsulation and delivery
    He, Yuhai
    Wang, Chen
    Wu, Qiuhua
    Zhang, Guolin
    NANOTECHNOLOGY, 2024, 35 (31)
12345