N-(DIPHENOXYPHOSPHORYL)SUCCINIMIDE: SYNTHESIS AND REACTION WITH ALKOXIDES

被引:0
|
作者
Andruszkiewicz, Ryszard [1 ]
Liedke-Przybysz, Ewa [1 ]
机构
[1] Gdansk Univ Technol, Dept Pharmaceut Technol & Biochem, Gdansk, Poland
关键词
Phosphorylated succinimide; nucleophilic ring opening; phosphoramidates; N-PHOSPHORYL OXAZOLIDINONES; AGENTS;
D O I
10.1080/10426507.2011.608098
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
Reaction of succinimide with diphenylchlorophosphate in the presence of lithium bis(trimethylsilyl)amide followed by aqueous work-up led to the formation of amidophosphate 3. The same reaction performed in the presence of sodium hydride yield N-(diphenylphosphoryl)succinimde 4, which undergoes nucleophilic ring opening with sodium alkoxides resulted in the formation of phosphoroamidate analogues 5 a-d in good yields.
引用
收藏
页码:2274 / 2278
页数:5
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