Palladium-Catalyzed [3+2] Cycloaddition of Vinylaziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines

被引：16

作者：

Vetica, Fabrizio ^{[1
]}

Bailey, Stephen J. ^{[1
]}

Kumar, Mukesh ^{[1
]}

Mahajan, Suruchi ^{[1
]}

Rissanen, Kari ^{[2
]}

von Essen, Carolina ^{[2
]}

Enders, Dieter ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, Landoltweg 1, D-52074 Aachen, Germany

[2] Univ Jyvaskyla, Dept Chem, Nanosci Ctr, Jyu 40014, Finland

来源：

SYNTHESIS-STUTTGART | 2020年 / 52卷 / 14期

关键词：

palladium catalysis; asymmetric synthesis; aziridines; sprio-pyrrolidines; indane-1; 3-diones; VINYL AZIRIDINES; 1,3-DIPOLAR CYCLOADDITION; ONE-POT; INDOLIZIDINE; CONSTRUCTION; ALLENOATES; INHIBITOR; DISCOVERY;

D O I：

10.1055/s-0040-1707472

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mild and efficient palladium-catalyzed [3+2] cycloaddition of vinylaziridine and indane-1,3-diones has been realized. The resulting spiro-pyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio-- and diastereoselectivities.

引用

页码：2038 / 2044

页数：7

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