Differential effects of 5α-dihydrotesterosterone (DHT) and a novel selective androgen receptor modulator (SARM) on prostate and bone in intact and orchidectomized (ORX) male rats.

被引：0
|
作者：
Ke, HZ [1 ]
Crawford, DT [1 ]
Qi, H [1 ]
Simmons, HA [1 ]
Li, M [1 ]
Brown, TA [1 ]
Thompson, DD [1 ]
Wang, XN [1 ]
Salter, ED [1 ]
O'Malley, JP [1 ]
Salatto, CT [1 ]
Hill, RJ [1 ]
Lefker, BA [1 ]
Cameron, KO [1 ]
机构：
[1] Pfizer Global R&D, Groton, CT USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：S406 / S407
页数：2
相关论文
共 38 条
  • [31] A novel selective androgen receptor modulator, NEP28, is efficacious in muscle and brain without serious side effects on prostate
    Akita, Kazumasa
    Harada, Koichiro
    Ichihara, Junji
    Takata, Naoko
    Takahashi, Yasuhiko
    Saito, Koichi
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 720 (1-3) : 107 - 114
  • [32] Re: Effects of a Selective Androgen Receptor Modulator (SARM), GSK2849466A, on Stress Urinary Incontinence and Bladder Activity in Rats With Ovariectomy-Induced Oestrogen Deficiency
    Wein, Alan J.
    JOURNAL OF UROLOGY, 2021, 205 (03): : 936 - 936
  • [33] Idoxifene: A novel selective estrogen receptor modulator prevents bone loss and lowers cholesterol levels in ovariectomized rats and decreases uterine weight in intact rats
    Nuttall, ME
    Bradbeer, JN
    Stroup, GB
    Nadeau, DP
    Hoffman, SJ
    Zhao, H
    Rehm, S
    Gowen, M
    ENDOCRINOLOGY, 1998, 139 (12) : 5224 - 5234
  • [34] The Novel Non-steroidal Selective Androgen Receptor Modulator S-101479 Has Additive Effects with Bisphosphonate, Selective Estrogen Receptor Modulator, and Parathyroid Hormone on the Bones of Osteoporotic Female Rats
    Furuya, Kazuyuki
    Yamamoto, Noriko
    Ohyabu, Yuki
    Makino, Akito
    Morikyu, Teruyuki
    Ishige, Hirohide
    Kuzutani, Kazuya
    Endo, Yasuhisa
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2012, 35 (07) : 1096 - 1104
  • [35] Extraskeletal effects of the novel selective estrogen receptor modulator (SERM) bazedoxifene acetate (BZA): A 12-month study in ovariectomized rats.
    Komm, B. S.
    Minck, D. R.
    FERTILITY AND STERILITY, 2007, 88 : S242 - S242
  • [36] Pharmacological and x-ray structural characterization of a novel selective androgen receptor modulator: Potent hyperanabolic stimulation of skeletal muscle with hypostimulation of prostate in rats
    Ostrowski, Jacek
    Kuhns, Joyce E.
    Lupisella, John A.
    Manfredi, Mark C.
    Beehler, Blake C.
    Krystek, Stanley R., Jr.
    Bi, Yingzhi
    Sun, Chongqing
    Seethala, Ramakrishna
    Golla, Rajasree
    Sleph, Paul G.
    Fura, Aberra
    An, Yongmi
    Kish, Kevin F.
    Sack, John S.
    Mookhtiar, Kasim A.
    Grover, Gary J.
    Hamann, Lawrence G.
    ENDOCRINOLOGY, 2007, 148 (01) : 4 - 12
  • [37] 6-Carboxymethyl genistein: a novel selective oestrogen receptor modulator (SERM) with unique, differential effects on the vasculature, bone and uterus
    Somjen, D
    Amir-Zaltsman, Y
    Gayer, B
    Kulik, T
    Knoll, E
    Stern, N
    Lu, LJW
    Toldo, L
    Kohen, F
    JOURNAL OF ENDOCRINOLOGY, 2002, 173 (03) : 415 - 427
  • [38] A novel selective androgen receptor modulator (SARM) MK-4541 exerts anti-androgenic activity in the prostate cancer xenograft R-3327G and anabolic activity on skeletal muscle mass & function in castrated mice
    Chisamore, Michael J.
    Gentile, Michael A.
    Dillon, Gregory Michael
    Baran, Matthew
    Gambone, Carlo
    Riley, Sean
    Schmidt, Azriel
    Flores, Osvaldo
    Wilkinson, Hilary
    Alves, Stephen E.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2016, 163 : 88 - 97
1234