Differential effects of 5α-dihydrotesterosterone (DHT) and a novel selective androgen receptor modulator (SARM) on prostate and bone in intact and orchidectomized (ORX) male rats.

被引：0

作者：

Ke, HZ ^{[1
]}

Crawford, DT ^{[1
]}

Qi, H ^{[1
]}

Simmons, HA ^{[1
]}

Li, M ^{[1
]}

Brown, TA ^{[1
]}

Thompson, DD ^{[1
]}

Wang, XN ^{[1
]}

Salter, ED ^{[1
]}

O'Malley, JP ^{[1
]}

Salatto, CT ^{[1
]}

Hill, RJ ^{[1
]}

Lefker, BA ^{[1
]}

Cameron, KO ^{[1
]}

机构：

[1] Pfizer Global R&D, Groton, CT USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 09期

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：S406 / S407

页数：2

共 38 条

[1] A novel, nonsteroidal selective androgen receptor modulator (SARM) increases periosteal bone formation and inhibits trabecular bone turnover in aged intact and orchidectomized male rats
Ke, HZ
Crawford, DT
Qi, H
Simmons, HA
Li, M
Brown, TA
Salter, ED
O'Malley, JP
Salatto, CT
Lefker, BA
Gant, TG
Hill, RJ
Wang, XN
Thompson, DD
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S56 - S56
[2] LGD2941 is a potent, orally-available selective androgen receptor modulator (SARM) with superior activity in bone and muscle in male rats.
Chang, W. Y.
Vajda, E. G.
Burnett, K.
Talaoc, E. C.
Mais, D. E.
Marschke, K.
Lopez, F. J.
Viveros, O. H.
Shen, Y.
Martinborough, E.
Hudson, A.
Zhi, L.
Negro-Vilar, A.
JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 : S426 - S426
[3] Effects of Selective Androgen Receptor Modulator (SARM) Treatment in Osteopenic Female Rats
Kearbey, Jeffrey D.
Gao, Wenqing
Fisher, Scott J.
Wu, Di
Miller, Duane D.
Dalton, James T.
PHARMACEUTICAL RESEARCH, 2009, 26 (11) : 2471 - 2477
[4] Effects of Selective Androgen Receptor Modulator (SARM) Treatment in Osteopenic Female Rats
Jeffrey D. Kearbey
Wenqing Gao
Scott J. Fisher
Di Wu
Duane D. Miller
James T. Dalton
Pharmaceutical Research, 2009, 26 : 2471 - 2477
[5] A selective androgen receptor modulator with minimal prostate hypertrophic activity restores lean body mass in aged orchidectomized male rats
Allan, George
Sbriscia, Tifanie
Linton, Olivia
Lai, Muh-Tsann
Haynes-Johnson, Donna
Bhattacharjee, Sheela
Ng, Raymond
Sui, Zhihua
Lundeen, Scott
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2008, 110 (3-5): : 207 - 213
[6] Bone and muscle protection and prostate-sparing effects of the selective androgen receptor modulator (SARM) 7α-methyl-19-nortestosterone:: Evidence from the aged orchidectomized male rat model.
Venken, K
Boonen, S
Van Herck, E
Vandenput, L
Kumar, N
Sitruk-Ware, R
Sundaram, K
Bouillon, R
Vanderschueren, D
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 : S478 - S479
[7] Differential effects on bone of estrogen receptor α and androgen receptor activation in orchidectomized adult male mice
Movérare, S
Venken, K
Eriksson, AL
Andersson, N
Skrtic, S
Wergedal, I
Mohan, S
Salmon, P
Bouillon, R
Gustafsson, JÅ
Vanderschueren, D
Ohlsson, C
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) : 13573 - 13578
[8] Selective Androgen Receptor Modulator (SARM) treatment prevents bone loss and reduces body fat in ovariectomized rats
Kearbey, Jeffrey D.
Gao, Wenqing
Narayanan, Ramesh
Fisher, Scott J.
Wu, Di
Miller, Duane D.
Dalton, James T.
PHARMACEUTICAL RESEARCH, 2007, 24 (02) : 328 - 335
[9] Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats
Jeffrey D. Kearbey
Wenqing Gao
Ramesh Narayanan
Scott J. Fisher
Di Wu
Duane D. Miller
James T. Dalton
Pharmaceutical Research, 2007, 24 : 328 - 335
[10] Bone anabolic effects of S-40503, a novel nonsteroidal selective androgen receptor modulator (SARM), in rat models of osteoporosis
Hanada, K
Furuya, K
Yamamoto, N
Nejishima, H
Ichikawa, K
Nakamura, T
Miyakawa, M
Amano, S
Sumita, Y
Oguro, N
BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2003, 26 (11) : 1563 - 1569

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