TNNI3K in cardiovascular disease and prospects for therapy

被引：15
|
作者：
Milano, Annalisa [1 ]
Lodder, Elisabeth M. [1 ]
Bezzina, Connie R. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Clin & Expt Cardiol, NL-1105 AZ Amsterdam, Netherlands
来源：
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY | 2015年 / 82卷
关键词：
Tnni3k; Heart failure; Ischemia/reperfusion; Arrhythmia; Kinase; KINASE; LOCI; REVEALS; CLONING; MICE; OVEREXPRESSION; CARDIOMYOPATHY; SUSCEPTIBILITY; MECHANISMS; EXPRESSION;
D O I：
10.1016/j.yjmcc.2015.03.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cardiovascular diseases are an important cause of morbidity and mortality worldwide and the global burden of these diseases continues to grow. Therefore new therapies are urgently needed. The role of protein kinases in disease, including cardiac disease, is long recognized, making kinases important therapeutic targets. We here review the knowledge gathered in the last decade about troponin I-interacting kinase (TNNI3K), a kinase with cardiac-restricted expression that has been implicated in various cardiac phenotypes and diseases including heart failure, cardiomyopathy, ischemia/reperfusion injury and conduction of the cardiac electrical impulse. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：167 / 173
页数：7
相关论文
共 50 条
  • [41] Promotion of myocardial contractile force by overexpression of MAP kinase TNNI3K gene and its involved mechanisms
    Lai, Zhong-Fang
    Chen, Yu-Zhen
    Meng, Xian-Min
    Ding, Jin-Feng
    Li, Ping
    Cheng, Xiao-Shu
    Kim-Mitsuyama, Shokei
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2009, 109 : 76P - 76P
  • [42] Whole exome sequencing identifies the TNNI3K gene as a cause of familial conduction system disease and congenital junctional ectopic tachycardia
    Xi, Yanwei
    Honeywell, Christina
    Zhang, Dapeng
    Schwartzentruber, Jeremy
    Beaulieu, Chandree L.
    Tetreault, Martine
    Hartley, Taila
    Marton, Jennifer
    Vidal, Silvia M.
    Majewski, Jacek
    Aravind, L.
    Gollob, Michael
    Boycott, Kym M.
    Gow, Robert M.
    INTERNATIONAL JOURNAL OF CARDIOLOGY, 2015, 185 : 114 - 116
  • [43] MAP kinase TNNI3K functional analysis and new drug development for suppressing cardiac sudden death
    Lai, Zhong-Fang
    Chen, Yu-Zhen
    Zhang, Tian-Li
    Sakaguchi, Nobuo
    Kim-Mitsuyama, Shokei
    Kitamoto, Yasunori
    JOURNAL OF PHARMACOLOGICAL SCIENCES, 2014, 124 : 158P - 158P
  • [44] Dissection of a Quantitative Trait Locus for PR Interval Duration Identifies Tnni3k as a Novel Modulator of Cardiac Conduction
    Lodder, Elisabeth M.
    Scicluna, Brendon P.
    Milano, Annalisa
    Sun, Albert Y.
    Tang, Hao
    Remme, Carol Ann
    Moerland, Perry D.
    Tanck, Michael W. T.
    Pitt, Geoffrey S.
    Marchuk, Douglas A.
    Bezzina, Connie R.
    PLOS GENETICS, 2012, 8 (12):
  • [45] 4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors
    Philp, Joanne
    Lawhorn, Brian G.
    Graves, Alan P.
    Shewchuk, Lisa
    Rivera, Katrina L.
    Jolivette, Larry J.
    Holt, Dennis A.
    Gatto, Gregory J., Jr.
    Kallander, Lara S.
    JOURNAL OF MEDICINAL CHEMISTRY, 2018, 61 (07) : 3076 - 3088
  • [46] Overexpression of Cardiac-Specific Kinase TNNI3K Promotes Mouse Embryonic Stem Cells Differentiation into Cardiomyocytes
    Wang, Yin
    Wang, Shi-qiang
    Wang, Li-peng
    Yao, Yu-hong
    Ma, Chun-yan
    Ding, Jin-feng
    Ye, Jue
    Meng, Xian-min
    Li, Jian-jun
    Xu, Rui-xia
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2017, 41 (01) : 381 - 398
  • [47] New Insights into 4-Anilinoquinazolines as Inhibitors of Cardiac Troponin I-Interacting Kinase (TNNi3K)
    Asquith, Christopher R. M.
    Laitinen, Tuomo
    Wells, Carrow I.
    Tizzard, Graham J.
    Zuercher, William J.
    MOLECULES, 2020, 25 (07):
  • [48] ACE2, CALM3 and TNNI3K polymorphisms as potential disease modifiers in hypertrophic and dilated cardiomyopathies (vol 438, pg 167, 2018)
    Kumar, Amit
    Rani, Bindu
    Sharma, Rajni
    Kaur, Gurjeet
    Prasad, Rishikesh
    Bahl, Ajay
    Khullar, Madhu
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2019, 450 (1-2) : 209 - 210
  • [49] The overexpression of cardiomyocyte-specific kinase TNNI3K promotes mouse embryonic stem cells differentiation into cardiomyocytes
    Wang, Y.
    Xu, R. X.
    EUROPEAN HEART JOURNAL, 2017, 38 : 532 - 532
  • [50] Altered auto-phosphorylation of novel TNNI3K variants associated with AV-nodal re-entry tachycardia and conduction disease
    Pham, C.
    Munoz-Martin, N.
    Podliesna, S.
    Milano, A.
    Beekman, L.
    Vermeer, A.
    Frantzen, C.
    Jansen, S.
    Van De Laar, I
    Nieuwhof, K.
    Christiaans, I
    Bezzina, C. R.
    Lodder, E. M.
    EUROPEAN HEART JOURNAL, 2020, 41 : 339 - 339
12345