A family-based association study of schizophrenia with polymorphisms at three candidate genes

被引：42
|
作者：
Duan, SW
Gao, R
Xing, QH
Du, J
Liu, ZJ
Chen, Q
Wang, HS
Feng, GY
He, L
机构：
[1] Chinese Acad Sci, SIBS, Inst Nutr Sci, Shanghai 200031, Peoples R China
[2] Shanghai Jiao Tong Univ, BioX Life Sci Res Ctr, NHGG, Shanghai 200030, Peoples R China
[3] Shanghai Inst Mental Hlth, Shanghai 200030, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2005年 / 379卷 / 01期
基金：
中国国家自然科学基金;
关键词：
NPY; YWHAH; PIK3C3; polymorphism; schizophrenia; family-based; gender;
D O I：
10.1016/j.neulet.2004.12.040
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Clinical researches have shown that there is a genetic contribution to the pathogenesis of schizophrenia. Recent studies have suggested that three genes neuropeptide Y (NPY), phosphoinositide-3-kinase class 3 (PIK3C3) and 14-3-3 eta chain gene (YWHAH) are probably associated with schizophrenia. To replicate these findings, we carried out a family-based study on a sample of 235 trios. Our results suggest that the polymorphisms at the NPY and YWHAH genes are unlikely to be linked with genetic susceptibility to schizophrenia. However, we found significant evidence of preferential transmission of the -432C allele of the PIK3C3 gene in the entire trios (Z = 2.91, d.f. = 1, P = 0.0036) and the male probands trios (Z = 2.66, d.f. = 1, P = 0.0079). (c) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：32 / 36
页数：5
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