Molecular Plumbing to Bend Self-Assembling Peptide Nanotubes

被引：12
|
作者：
Novelli, Federica [1 ,2 ]
Vilela, Marcos [1 ,2 ]
Pazo, Antia [1 ,2 ]
Amorin, Manuel [1 ,2 ]
Granja, Juan R. [1 ,2 ]
机构：
[1] Univ Santiago De Compostela, Ctr Singular Invest Quim Biol & Mat Mol CIQUS, Santiago De Compostela 15782, Spain
[2] Univ Santiago De Compostela, Dept Organ Chem, Santiago De Compostela 15782, Spain
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2021年 / 60卷 / 34期
关键词：
cyclic peptides; molecular plumbing; nanotubes; photodimerization; self-assembly; E-Z ISOMERIZATION; CYCLIC-PEPTIDE; BETA-PEPTIDES; LIGHT; PHOTODIMERIZATION; ANTHRACENES; PARALLEL; BEHAVIOR; PHOTOCYCLOADDITION; DIFFERENTIATION;
D O I：
10.1002/anie.202107034
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Light-induced molecular piping of cyclic peptide nanotubes to form bent tubular structures is described. The process is based on the [4+4] photocycloaddition of anthracene moieties, whose structural changes derived from the interdigitated flat disposition of precursors to the corresponding cycloadduct moieties, induced the geometrical modifications in nanotubes packing that provokes their curvature. For this purpose, we designed a new class of cyclic peptide nanotubes formed by beta- and alpha-amino acids. The presence of the former predisposes the peptide to stack in a parallel fashion with the beta-residues aligned along the nanotube and the homogeneous distribution of anthracene pendants.
引用
收藏
页码：18838 / 18844
页数：7
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