Transmembrane ion transport by self-assembling α,γ-peptide nanotubes

被引：67
|
作者：
Garcia-Fandino, Rebeca
Amorin, Manuel [1 ]
Castedo, Luis
Granja, Juan R.
机构：
[1] Univ Santiago de Compostela, Dept Quim Organ, Ctr Singular Invest Quim Biol & Mat Mol CIQUS, Santiago De Compostela 15782, Spain
来源：
CHEMICAL SCIENCE | 2012年 / 3卷 / 11期
关键词：
CYCLIC PEPTIDE NANOTUBES; MOLECULAR-DYNAMICS; CHANNELS; WATER; SELECTIVITY; GRAMICIDIN; PERMEATION; SIMULATION; PRINCIPLES; DIFFUSION;
D O I：
10.1039/c2sc21068a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this study, we describe the self-assembling properties of cyclic peptides containing gamma-amino acids in lipid bilayers to form transmembrane nanotubes. The resulting ion channel models are selective for alkaline ions. Although the transport rates conform to the lyotropic series, these partially hydrophobic channels show an unexpectedly higher rate for sodium ions.
引用
收藏
页码：3280 / 3285
页数：6
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