Salusin-β mediate neuroprotective effects for Parkinson's disease

被引：8
|
作者：
Chang, Yujung [1 ]
Yoo, Junsang [1 ]
Kim, Hongwon [1 ]
Park, Hi-Joon [3 ]
Jeon, Songhee [4 ]
Kim, Jongpil [1 ,2 ]
机构：
[1] Dongguk Univ, Dept Biomed Engn Plus BK21, Lab Stem Cells & Cell Reprogramming, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea
[2] Dongguk Univ, Dept Chem, 30 Pildong Ro 1 Gil, Seoul 04620, South Korea
[3] Kyung Hee Univ, Grad Sch Korean Med, Dept Korean Med Sci, Acupuncture & Meridian Sci Res Ctr, 26 Kyungheedae Ro, Seoul 02447, South Korea
[4] Chonnam Natl Univ, Ctr Creat Biomed Scientists, Dept Biomed Sci, Gwangju 61469, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 503卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
Parkinson's disease; Neuropeptide; Salusin-beta; Neuroprotective effect;
D O I：
10.1016/j.bbrc.2018.07.059
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuropeptides, small peptides found in many mammalian brain, play key roles in communicating with each other to modulate neuronal activity. Here, we reported that endogenous neuropeptide salusin-beta has neuroprotective effects on the midbrain dopamine neurons and can be used as an effective therapeutic treatment for Parkinson's disease (PD). We found that the MrgprA1 receptor mediates the neuroprotective effects of salusin-beta on the midbrain dopamine neurons. Importantly, intranasal administration of salusin-beta in a PD mouse model show the neuroprotection of dopaminergic neurons and increased the survival of midbrain dopamine neurons. Furthermore, inhibition of the salusin-beta receptor, MrgprA1, abolished the neuroprotective effects induced by salusin-beta. Taken together, these results demonstrate the novel role of salusin-beta in the central nervous system and salusin-beta can be used as a novel therapeutic to effectively treat PD. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：1428 / 1433
页数：6
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