What do unicellular organisms teach us about DNA methylation?

被引：6
|
作者：
Harony, Hala [1 ]
Ankri, Serge [1 ]
机构：
[1] Technion Israel Inst Technol, Rappaport Inst, Ruth & Bruce Rappaport Fac Med, Dept Microbiol, IL-31096 Haifa, Israel
来源：
TRENDS IN PARASITOLOGY | 2008年 / 24卷 / 05期
关键词：
D O I：
10.1016/j.pt.2008.02.002
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
DNA methylation is an epigenetic hallmark that has been studied intensively in mammals and plants. However, knowledge of this phenomenon in unicellular organisms is scanty. Examining epigenetic regulation, and more specifically DNA methylation, in these organisms represents a unique opportunity to better understand their biology. The determination of their methylation status is often complicated by the presence of several differentiation stages in their life cycle. This article focuses on some recent advances that have revealed the unexpected nature of the epigenetic determinants present in protozoa. The role of the enigmatic DNA methyltransferase Dnmt2 in unicellular organisms is discussed.
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页码：205 / 209
页数：5
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