Polymeric siRNA delivery vectors: knocking down cancers with polymeric-based gene delivery systems

被引：12

作者：

Ardana, Aditya ^{[1
,2
]}

Whittaker, Andrew K. ^{[1
,2
,4
]}

McMillan, Nigel A. J. ^{[3
]}

Thurecht, Kristofer J. ^{[1
,2
,4
]}

机构：

[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia

[2] Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072, Australia

[3] Griffith Univ, Sch Med Sci, Southport, Qld 4222, Australia

[4] Univ Queensland, ARC Ctr Excellence Convergent Bionano Sci & Techn, St Lucia, Qld 4072, Australia

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2015年 / 90卷 / 07期

基金：

澳大利亚研究理事会;

关键词：

siRNA; polymers; macromolecules; gene therapy; dendrimers; INTERFERING RNA SIRNA; IN-VIVO DELIVERY; GOLD NANOPARTICLES; RAFT POLYMERIZATION; MAMMALIAN-CELLS; INTRACELLULAR DELIVERY; CHEMICAL-MODIFICATIONS; REVERSIBLE ADDITION; COMPLEX MICELLES; RATIONAL DESIGN;

D O I：

10.1002/jctb.4508

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy. (c) 2014 Society of Chemical Industry

引用

页码：1196 / 1208

页数：13

共 50 条

[31] Enhancers in polymeric nonviral gene delivery systems
Yang, Zhiyu
Guo, Zhaopei
Tian, Huayu
Chen, Xuesi
[J]. VIEW, 2021, 2 (01)
[32] Current status of polymeric gene delivery systems
Park, Tae Gwan
Jeong, Ji Hoon
Kim, Sung Wan
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2006, 58 (04) : 467 - 486
[33] Peptide-based targeted polymeric nanoparticles for siRNA delivery
Hussein, Waleed M.
Cheong, Yee S.
Liu, Chang
Liu, Genan
Begum, Anjuman Ara
Attallah, Maria Adly
Moyle, Peter M.
Torchilin, Vladimir P.
Smith, Roger
Toth, Istvan
[J]. NANOTECHNOLOGY, 2019, 30 (41)
[34] Development of Polymeric-Based Formulation as Potential Smart Colonic Drug Delivery System
Bayan, Mohammad F.
Marji, Saeed M.
Salem, Mutaz S.
Begum, M. Yasmin
Chidambaram, Kumarappan
Chandrasekaran, Balakumar
[J]. POLYMERS, 2022, 14 (17)
[35] Delivery of siRNA from lyophilized polymeric surfaces
Andersen, Morten O.
Howard, Kenneth A.
Paludan, Soren R.
Besenbacher, Flemming
Kjems, Jorgen
[J]. BIOMATERIALS, 2008, 29 (04) : 506 - 512
[36] Non-condensing polymeric nanoparticles for targeted gene and siRNA delivery
Xu, Jing
Ganesh, Shanthi
Amiji, Mansoor
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2012, 427 (01) : 21 - 34
[37] Polymeric nanoparticles for siRNA delivery: Production and applications
Cavallaro, Gennara
Sardo, Carla
Craparo, Emanuela Fabiola
Porsio, Barbara
Giammona, Gaetano
[J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2017, 525 (02) : 313 - 333
[38] Multifunctional polymeric micelles for delivery of drugs and siRNA
Jhaveri, Aditi M.
Torchilin, Vladimir P.
[J]. FRONTIERS IN PHARMACOLOGY, 2014, 5
[39] siRNA drug delivery by biodegradable polymeric nanoparticles
Yuan, Xudong
Li, Ling
Rathinavelu, Appu
Hao, Jinsong
Narasimhan, Madhusudhanan
He, Matthew
Heitlage, Viviene
Tam, Linda
Viqar, Sana
Salehi, Mojgan
[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2006, 6 (9-10) : 2821 - 2828
[40] Polymeric Nanocarriers for siRNA Delivery to Murine Macrophages
Forbes, Diane C.
Peppas, Nicholas A.
[J]. MACROMOLECULAR BIOSCIENCE, 2014, 14 (08) : 1096 - 1105

← 1 2 3 4 5 →