Polymeric siRNA delivery vectors: knocking down cancers with polymeric-based gene delivery systems

被引：12
|
作者：
Ardana, Aditya [1 ,2 ]
Whittaker, Andrew K. [1 ,2 ,4 ]
McMillan, Nigel A. J. [3 ]
Thurecht, Kristofer J. [1 ,2 ,4 ]
机构：
[1] Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
[2] Univ Queensland, Ctr Adv Imaging, St Lucia, Qld 4072, Australia
[3] Griffith Univ, Sch Med Sci, Southport, Qld 4222, Australia
[4] Univ Queensland, ARC Ctr Excellence Convergent Bionano Sci & Techn, St Lucia, Qld 4072, Australia
来源：
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2015年 / 90卷 / 07期
基金：
澳大利亚研究理事会;
关键词：
siRNA; polymers; macromolecules; gene therapy; dendrimers; INTERFERING RNA SIRNA; IN-VIVO DELIVERY; GOLD NANOPARTICLES; RAFT POLYMERIZATION; MAMMALIAN-CELLS; INTRACELLULAR DELIVERY; CHEMICAL-MODIFICATIONS; REVERSIBLE ADDITION; COMPLEX MICELLES; RATIONAL DESIGN;
D O I：
10.1002/jctb.4508
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
One of the most promising routes for cancer therapy that has evolved over the previous decade is the use of small-interfering RNA (siRNA) as a means of switching off genes that are responsible for tumour development. However, while siRNA and gene/antisense therapies provide alternatives to conventional chemotherapies, significant hurdles related to the delivery and efficacy of treatment must still be overcome before this technology can be used as an effective treatment for cancer and other diseases. This review highlights the issues associated with siRNA therapy in vivo, and describes the various approaches that are being explored using polymers as delivery vectors. In particular, the review focuses on targeted delivery as a means of improving efficacy of the gene therapy. (c) 2014 Society of Chemical Industry
引用
收藏
页码：1196 / 1208
页数：13
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