N-Heterocyclic carbene palladium-catalyzed cascade annulation/alkynylation of 2-alkynylanilines with terminal alkynes

被引：25

作者：

Li, Jianxiao ^{[1
]}

Li, Can ^{[1
]}

Ouyang, Lu ^{[1
]}

Li, Chunsheng ^{[1
]}

Wu, Wanqing ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] South China Univ Technol, Sch Chem & Chem Engn, Key Lab Funct Mol Engn Guangdong Prov, Guangzhou 510640, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2017年 / 15卷 / 37期

基金：

中国国家自然科学基金;

关键词：

C-H ALKYNYLATION; CARBOXYLIC-ACIDS; DECARBOXYLATIVE ALKYNYLATION; SONOGASHIRA REACTIONS; PHOTOREDOX CATALYSIS; MOLECULAR-OXYGEN; C(SP(3))-H BONDS; ROOM-TEMPERATURE; GAMMA-LACTONES; BETA-CARBOLINE;

D O I：

10.1039/c7ob01889d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A straightforward and highly effective N-heterocyclic carbene-palladium catalyzed cascade annulation/alkynylation of 2-alkynylanilines with terminal alkynes has been enabled to afford free (NH)-3-alkynylindole derivatives in moderate to good yields. This protocol features mild conditions, broad substrate scope, and high atom-and step- economy. Notably, the resultant 3-alkynylindoles could be conveniently transformed into a variety of functionalized indole scaffolds, thus illustrating their potential applications in synthetic and pharmaceutical chemistry.

引用

页码：7898 / 7908

页数：11

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