Engineering tolerance and accumulation of lead and cadmium in transgenic plants

被引：235
|
作者：
Song, WY
Sohn, EJ
Martinoia, E
Lee, YJ
Yang, YY
Jasinski, M
Forestier, C
Hwang, I
Lee, Y [1 ]
机构：
[1] POSTECH, Div Mol Life Sci, Natl Res Lab Phytoremediat, Pohang 790784, South Korea
[2] POSTECH, Ctr Plant Intracellular Trafficking, Pohang 790784, South Korea
[3] Univ Zurich, Inst Pflanzenbiol, CH-8008 Zurich, Switzerland
[4] CEA Cadarache, DEVM LEMS, CNRS, UMR 163, F-13108 St Paul Les Durance, France
来源：
NATURE BIOTECHNOLOGY | 2003年 / 21卷 / 08期
关键词：
D O I：
10.1038/nbt850
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
We have studied the utility of the yeast protein YCF1, which detoxifies cadmium by transporting it into vacuoles, for the remediation of lead and cadmium contamination. We found that the yeast YCF1-deletion mutant DTY167 was hypersensitive to Pb(II) as compared with wild-type yeast. DTY167 cells overexpressing YCF1 were more resistant to Pb( II) and Cd( II) than were wild-type cells, and accumulated more lead and cadmium. Analysis of transgenic Arabidopsis thaliana plants overexpressing YCF1 showed that YCF1 is functionally active and that the plants have enhanced tolerance of Pb( II) and Cd( II) and accumulated greater amounts of these metals. These results suggest that transgenic plants expressing YCF1 may be useful for phytoremediation of lead and cadmium.
引用
收藏
页码：914 / 919
页数：6
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