Recent Advances in the Development of Small-molecule CCR5 Inhibitors for HIV

被引：11
|
作者：
Liu, Tao [1 ]
Weng, Zhiyong [1 ]
Dong, Xiaowu [1 ]
Hu, Yongzhou [1 ]
机构：
[1] Zhejiang Univ, Coll Pharmaceut Sci, ZJU ENS Joint Lab Med Chem, Hangzhou 310058, Zhejiang, Peoples R China
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2010年 / 10卷 / 13期
关键词：
HIV; Entry; Co-receptor; CCR5; Small-molecule inhibitor; Maraviroc; IMMUNODEFICIENCY-VIRUS TYPE-1; CHEMOKINE RECEPTOR ANTAGONISTS; INFECTION IN-VITRO; BIOLOGICAL EVALUATION; ANTI-HIV-1; AGENTS; HIGHLY POTENT; ANTIVIRAL ACTIVITY; ENTRY INHIBITORS; VIRAL ENTRY; PART;
D O I：
10.2174/13895575110091277
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
CCR5 (C-C chemokine receptor type 5) is a chemokine receptor that has been identified as a major HIV coreceptor in viral entry and therefore is a highly validated target for the development of new anti-HIV drugs. Here, we discuss the insights gained so far relevant to the development of small-molecule CCR5 inhibitors for the treatment of HIV, and highlight small-molecule CCR5 inhibitors that are currently under preclinical and clinical trials.
引用
收藏
页码：1277 / 1292
页数：16
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