Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

被引：80

作者：

Sun, Jingyao ^{[1
,2
]}

Kormakov, Semen ^{[1
]}

Liu, Ying ^{[3
]}

Huang, Yao ^{[1
]}

Wu, Daming ^{[1
,3
]}

Yang, Zhaogang ^{[2
]}

机构：

[1] Beijing Univ Chem Technol, Coll Mech & Elect Engn, Beijing 100029, Peoples R China

[2] Ohio State Univ, Dept Chem & Biomol Engn, Columbus, OH 43210 USA

[3] State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China

来源：

MOLECULES | 2018年 / 23卷 / 07期

基金：

中国国家自然科学基金;

关键词：

photodynamic therapy; metal-based nanoparticles; potential toxicity; CORE-SHELL NANOPARTICLES; IMMUNOGENIC CELL-DEATH; GOLD NANOPARTICLES; ORGANIC FRAMEWORK; SINGLET OXYGEN; SILVER NANOPARTICLES; TISSUE DISTRIBUTION; SUBCELLULAR-LOCALIZATION; RUTHENIUM(II) COMPLEXES; STAPHYLOCOCCUS-AUREUS;

D O I：

10.3390/molecules23071704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

引用

页数：23

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