Acetyl chloride-mediated synthesis of trans-2-[(diethoxyphosphorylamino)alkyl]-4-aryl-5,5-dimethyl-1,3,2λ5-dioxaphosphorinane-2-oxide

被引：4
|
作者：
Miao, Zhiwei [1 ]
Zhang, Jianfeng [1 ]
Cui, Zhanwei [1 ]
Chen, Ruyu [1 ]
机构：
[1] Nankai Univ, Res Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN | 2008年 / 81卷 / 05期
关键词：
D O I：
10.1246/bcsj.81.630
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Phosphoramino-protected six-membered cyclic alpha-aminophosphonates trans-2-[(diethoxyphosphorylamino)-alkyll-4-aryl-5,5-dimethyl-1,3,2 lambda(5)-dioxaphosphorinane-2-oxide 4a-4l were synthesized with the help of acetyl chloride. (PNMR)-P-31 was used to trace the reaction process. A possible reaction mechanism was proposed and the stereochemistry of the title compounds was studied. In order to confirm the structure of 4, products 4f and 4k were recrystallized and determined by X-ray diffraction analysis.
引用
收藏
页码：630 / 635
页数：6
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