A straightforward click-approach towards pretubulysin-analogues

被引：14

作者：

Burkhart, Jens L. ^{[1
]}

Kazmaier, Uli ^{[1
]}

机构：

[1] Univ Saarland, Inst Organ Chem, D-66123 Saarbrucken, Germany

来源：

RSC ADVANCES | 2012年 / 2卷 / 09期

关键词：

METASTATIC BREAST-CANCER; ADVANCED SOLID TUMORS; DOLASTATIN; 10; ANGIOCOCCUS-DISCIFORMIS; BIOLOGICAL-PROPERTIES; POTENTIAL ANTICANCER; TUBULYSIN ANALOGS; PEPTIDE-SYNTHESIS; TUBULIN-BINDING; NATURAL-PRODUCT;

D O I：

10.1039/c2ra20191g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The [3+2]-cycloaddition of an azido tripeptide, corresponding to the left hand side of pretubulysin, with a range of alkynes, such as propiolic acid amides and propargyl ethers, allows the straightforward syntheses of libraries of tubulysin derivatives. Via this click approach, a chimera of pretubulysin and dolastatin 10, both highly potent antimitotic drug candidates, also becomes accessible.

引用

页码：3785 / 3790

页数：6

共 50 条

[31] Stereocontrolled preparation of bicyclic alkaloid analogues: an approach towards the kinabalurine skeleton
Evans, Paul
Kavanagh, Yvonne
O'Brien, Matthew
TETRAHEDRON, 2009, 65 (39) : 8259 - 8268
[32] A straightforward, eco-friendly and cost-effective approach towards flame retardant epoxy resins
Carja, Ionela-Daniela
Serbezeanu, Diana
Vlad-Bubulac, Tachita
Hamciuc, Corneliu
Coroaba, Adina
Lisa, Gabriela
Guillem Lopez, Celia
Fuensanta Soriano, Monica
Forrat Perez, Vicente
Romero Sanchez, Maria Dolores
JOURNAL OF MATERIALS CHEMISTRY A, 2014, 2 (38) : 16230 - 16241
[33] CuAAC click chemistry: a versatile approach towards PVDF-based block copolymers
Terzic, I.
Meereboer, N. L.
Loos, K.
POLYMER CHEMISTRY, 2018, 9 (27) : 3714 - 3720
[34] A Straightforward Approach towards Isoxazoline Amino Acid Esters by Domino Michael Additions/Nitrile Oxide Cycloadditions
Wirtz, Lisa
Kazmaier, Uli
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2011, 2011 (19) : 3467 - 3473
[35] A straightforward approach towards Si@C/graphene nanocomposite and its superior lithium storage performance
Li, Hai
Lu, Chunxiang
Zhang, Baoping
ELECTROCHIMICA ACTA, 2014, 120 : 96 - 101
[36] A Straightforward Approach towards Substituted Morita-Baylis-Hillman Products via Hydrostannation of Acetylenic Ketones
Lakshmi, B. Vasantha
Kazmaier, Uli
SYNLETT, 2010, (03) : 407 - 410
[37] A straightforward approach towards piperidines via Stille coupling and subsequent 1,4-addition of amines
Dörrenbächer, S
Kazmaier, U
Ruf, S
SYNLETT, 2006, (04) : 547 - 550
[38] Cyclononitols: a flexible synthetic approach towards nine-membered carbasugar analogues
Mehta, Goverdhan
Pallavi, Kotapalli
Katukojvala, Sreenivas
TETRAHEDRON LETTERS, 2009, 50 (31) : 4519 - 4522
[39] Synthesis of polyhydroxy piperidines and their analogues:: a novel approach towards selective inhibitors of α-glucosidase
Pandey, Ganesh
Bharadwaj, Kishor Chandra
Khan, M. Islam
Shashidhara, K. S.
Puranik, Vedavati G.
ORGANIC & BIOMOLECULAR CHEMISTRY, 2008, 6 (14) : 2587 - 2595
[40] A Click Chemistry Approach towards Flavin-Cyclodextrin Conjugates-Bioinspired Sulfoxidation Catalysts
Tomanova, Petra
Sturala, Jiri
Budesinsky, Milos
Cibulka, Radek
MOLECULES, 2015, 20 (11): : 19837 - 19848

← 1 2 3 4 5 →