Enantioselective bromolactonization of cis-1,2-disubstituted olefinic acids using an amino-thiocarbamate catalyst

被引：107
|
作者：
Tan, Chong Kiat [1 ]
Le, Chencheng [1 ]
Yeung, Ying-Yeung [1 ]
机构：
[1] NUS, Dept Chem, Singapore 11754, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 46期
关键词：
ASYMMETRIC BROMOLACTONIZATION; BROMOCYCLIZATION; HALOCYCLIZATION; (+)-CP-99,994; HALOGENATION; ANTAGONIST; STRATEGIES; REDUCTION; KETONES; DESIGN;
D O I：
10.1039/c2cc31148h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A facile, highly regio- and enantioselective amino-thiocarbamate-catalyzed bromolactonization of cis-1,2-disubstituted olefinic acids has been developed. The use of the enantio-enriched lactones in the synthesis of chiral synthetic intermediates is also demonstrated.
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收藏
页码：5793 / 5795
页数：3
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