Novel CTNND2-TERT fusion in a spindle cell liposarcoma

被引:9
|
作者
Occidental, Michael [1 ]
Shen, Guomiao [1 ]
Feng, Xiaojun [1 ]
Zhu, Kelsey [1 ]
Kelly, Kevin [2 ]
Nie, Qian [2 ]
Reddi, Honey V. [2 ]
Lakiotaki, Eleftheria [3 ]
Viniou, Nora Athina [4 ]
Korkolopoulou, Penelope [3 ]
Linos, Konstantinos [5 ,6 ]
Jour, George [1 ,7 ]
机构
[1] New York Univ Langone Hlth, Dept Pathol, 240 E 38th St, New York, NY 10016 USA
[2] Jackson Lab, Farmington, CT USA
[3] Natl & Kapodistrian Univ Athens, Dept Pathol 1, Athens, Greece
[4] Natl & Kapodistrian Univ Athens, Dept Internal Med 1, Athens, Greece
[5] Dartmouth Hitchcock Med Ctr, Dept Pathol & Lab Med, Lebanon, NH 03766 USA
[6] Geisel Sch Med Dartmouth, Hanover, NH USA
[7] New York Univ Langone Hlth, Dept Dermatol, 240 E 38th St, New York, NY 10016 USA
来源
GENES CHROMOSOMES & CANCER | 2020年 / 59卷 / 09期
关键词
anchored multiplex PCR; CTNND2; gene fusion; RNA sequencing; spindle cell liposarcoma; TERT; ANCHORED MULTIPLEX; MOLECULAR ANALYSIS; TUMORS; SARCOMA; GENE;
D O I
10.1002/gcc.22856
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Soft tissue tumors can be categorized molecularly into two categories: tumors which are known to have recurrent molecular alterations and tumors which do not have consistent recurrent molecular alterations or translocations. These "nontranslocation" associated sarcomas are clinically more aggressive than their more stable counterparts. However, recent advances in RNA sequencing have discovered recurrent novel fusions within the latter group, namely TERT-TRIO fusions. Furthermore, a recent report discovered this fusion in a spindle cell liposarcoma. Our case describes a novel fusion of CTNND2, a neighbor gene of TRIO, and TERT in a spindle cell liposarcoma, and provides further evidence that spindle cell liposarcoma should be a distinct entity from dedifferentiated liposarcoma.
引用
收藏
页码:544 / 548
页数:5
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