Advances in treating the ischaemic diabetic foot

被引:9
|
作者
Papanas, Nikolaos [1 ]
Maltezos, Efstratios [1 ]
机构
[1] Democritus Univ Thrace, Dept Internal Med 2, Outpatient Clin Obes Diabet & Metab, Alexandroupolis, Greece
关键词
angiogenesis; diabetic foot; ischaemia; peripheral arterial disease;
D O I
10.2174/157016108783331330
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The diabetic foot remains a major cause of morbidity worldwide. Ischaemia due to peripheral arterial disease significantly contributes to its pathogenesis and natural history. Increased revascularisation has been decisive in improving outcomes. However, there is still a need for further improvement. Advances in the treatment of ischaemia in the diabetic foot include therapeutic angiogenesis, stem cell therapy and miscellaneous modalities. Angiogenesis has yielded encouraging results in the treatment of peripheral arterial disease, but it has not been studied enough in patients with diabetes. Choice of patients, reliable study endpoints, as well as safety of growth factors in diabetic patients, who have an excess risk of widespread vascular disease, need to be addressed more convincingly. Similar improvement is required in the other emerging therapeutic options. From a practical point of view, until novel modalities are available, increased vigilance and prompt aggressive revascularisation are indispensable to reduce the rate of amputations.
引用
收藏
页码:23 / 28
页数:6
相关论文
共 50 条
  • [41] Mortality in diabetic foot patients: Major difference between ischaemic and neuropathic patients
    Anagnostopoulos, D
    Foster, AVM
    Bates, M
    Doxford, M
    Wilson, S
    Edmonds, ME
    DIABETOLOGIA, 1999, 42 : A311 - A311
  • [42] Advances in traditional Chinese medicine as adjuvant therapy for diabetic foot
    Liu, Fa-Shun
    Li, Yue
    Guo, Xian-Shan
    Liu, Rui-Chen
    Zhang, Hong-Ya
    Li, Zhen
    WORLD JOURNAL OF DIABETES, 2022, 13 (10) : 851 - 860
  • [43] Advances in the development of medical dressings for the treatment of diabetic foot wounds
    Cai, Ming
    Liu, Zhao
    Sun, Xun
    Qi, Ying
    Mei, Xiaolong
    Liu, Su
    Zhang, Chunlin
    Zhang, Xin
    Zong, Zhiguo
    Ma, Pengpeng
    Wang, Tao
    Xu, Weiguo
    Zhang, Tao
    CHEMICAL ENGINEERING JOURNAL, 2024, 498
  • [44] Advances in Infections and Wound Healing for the Diabetic Foot: The Die Is Cast
    Papanas, Nikolaos
    Mani, Raj
    INTERNATIONAL JOURNAL OF LOWER EXTREMITY WOUNDS, 2013, 12 (02): : 83 - 86
  • [45] Treating Diabetic Foot Osteomyelitis: A Practical State-of-the-Art Update
    Lipsky, Benjamin A.
    Uckay, Ilker
    MEDICINA-LITHUANIA, 2021, 57 (04):
  • [46] A report from the international consensus on diagnosing and treating the infected diabetic foot
    Lipsky, BA
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2004, 20 : S68 - S77
  • [48] Use of phytotherapy in treating diabetic foot in older adults: an integrative review
    Pires, Jose Mateus
    Lopes, Gabriella Farias
    de Sousa, Caroline Ribeiro
    Oliveira, Francisco Gerlai Lima
    Souza, Rodrigo Lopes de Paula
    Coutinho, Janaina Fonseca Victor
    Marques, Marilia Braga
    REV RENE, 2023, 24
  • [49] Intensive versus conventional glycaemic control for treating diabetic foot ulcers
    Fernando, Malindu E.
    Seneviratne, Ridmee M.
    Tan, Yong Mong
    Lazzarini, Peter A.
    Sangla, Kunwarjit S.
    Cunningham, Margaret
    Buttner, Petra G.
    Golledge, Jonathan
    COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2016, (01):
  • [50] Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy
    Sherman, RA
    DIABETES CARE, 2003, 26 (02) : 446 - 451