Rhodium(III)-Catalyzed C-H Activation/Cylization of Indole-2-amides Derivatives and Terminal Alkynes

被引：7

作者：

Wang, Liang ^{[1
,2
]}

Qu, Xing ^{[1
]}

Li, Zhan ^{[1
]}

Peng, Wangming ^{[1
]}

机构：

[1] Jianghan Univ, Key Lab Optoelect Chem Mat & Devices, Minist Educ, Wuhan 430056, Peoples R China

[2] Jianghan Univ, Sch Chem & Enviromental Engn, Wuhan 430056, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 35卷 / 03期

基金：

中国国家自然科学基金;

关键词：

rhodium catalyst; oxidative directing group; C-H activation; polycyclic indoles; N BOND FORMATION; ISOQUINOLONE SYNTHESIS; ACTIVATION; FUNCTIONALIZATION; ARYLATION; BORYLATION; INDOLES; AIR;

D O I：

10.6023/cjoc201412023

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient Rh-catalyzed the C-H activation/cyclization reaction of indole-2-amides and alkynes was developed. A series of novel pyrido[3,4-b]indol-1-ones can be efficiently obtained with high to excellent yields using the internal oxidant at room temperature. The transformations have a wide range of substrates with various functional groups. Intermolecular competition experiment was conducted, and a plausible mechanism was proposed. The structures of all conpound were confirmed by H-1 NMR, C-13 NMR and HRMS.

引用

页码：688 / 697

页数：10

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