Practical Synthesis of PC190723, an Inhibitor of the Bacterial Cell Division Protein FtsZ

被引：21

作者：

Sorto, Nohemy A. ^{[1
]}

Olmstead, Marilyn M. ^{[1
]}

Shaw, Jared T. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 22期

关键词：

ASSEMBLY DYNAMICS; TARGETING FTSZ; TUBULIN;

D O I：

10.1021/jo101720y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A high-yielding and practical synthesis of the bacterial cell division inhibitor PC190723 is described The synthesis is completed in a longest linear sequence of five steps from commercially available starting materials and can be readily executed on a multigram scale

引用

页码：7946 / 7949

页数：4

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