Effects of an inhibitor of topoisomerase II, ICRF-193 on the formation of ultraviolet-induced chromosomal aberrations

被引：15
|
作者：
Ikushima, T
Shima, Y
Ishii, Y
机构：
[1] Kyoto Univ Educ, Div Biol, Fushimi Ku, Kyoto 6120863, Japan
[2] Osaka Univ, Fac Med, Dept Radiat Biol, Osaka 5650871, Japan
来源：
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS | 1998年 / 404卷 / 1-2期
关键词：
Chinese hamster cell; topoisomerase II inhibitor; ICRF-193; chromosomal aberration; UV;
D O I：
10.1016/S0027-5107(98)00092-X
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Treatments of Chinese hamster V79 cells during one cell cycle with a new type of topoisomerase II inhibitor, ICRF-193, which does not accumulate cleavable topoisomerase-DNA complexes induced both chromosome- and chromatid-type aberrations with high frequencies. Furthermore, ICRF-193 synergistically enhanced the yield of UVB-induced chromatid-type aberrations, chromatid exchanges in particular. Treated with ICRF-193 for the last 3 h before harvest, cells showed frequent incidence of chromatid-type aberrations and synergistic enhancement of UVB-induced chromatid-type aberrations, chromatid exchanges in particular. These results suggest that spontaneous and UVB-induced lesions might be ultimately transformed into chromatid-type aberrations by topoisomerase II-dependent checkpoint process(es) in the G(2) phase of the cell cycle. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：35 / 38
页数：4
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