1,4-benzodiazepin-2-ones in medicinal chemistry

被引：41
|
作者：
Spencer, John [1 ]
Rathnam, Rajendra P. [1 ]
Chowdhry, Babur Z. [1 ]
机构：
[1] Univ Greenwich Medway, Sch Sci, Chatham ME4 4TB, Kent, England
来源：
FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 09期
关键词：
RECEPTOR ANTAGONISTS; COMBINATORIAL SYNTHESIS; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; CCK2; ANTAGONISTS; HIGHLY POTENT; BENZODIAZEPINE; INHIBITORS; DERIVATIVES; NONPEPTIDE;
D O I：
10.4155/FMC.10.226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
引用
收藏
页码：1441 / 1449
页数：9
相关论文
共 50 条
  • [31] Synthesis, Structure, and Analgesic Properties of Phosphorylated Dihydro-1,4-Benzodiazepin-2-Ones*
    V. I. Pavlovskii
    Yu. G. Gololobov
    S. A. Andronati
    E. V. Voronenko
    T. A. Kabanova
    E. I. Khalimova
    I. Yu. Krasnova
    V. N. Khrustalev
    Pharmaceutical Chemistry Journal, 2016, 50 : 229 - 233
  • [32] QUINAZOLINES AND 1,4-BENZODIAZEPINES .69. 1-VINYL-1,4-BENZODIAZEPIN-2-ONES AND 1-VINYLQUINAZOLIN-2(1H)-ONES
    WALSER, A
    FRYER, RI
    JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (11) : 1228 - 1231
  • [33] 5-ARYL-1,5-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONES
    BELL, SC
    MCCAULLY, RJ
    CHILDRESS, SJ
    JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) : 172 - +
  • [34] Enantioselective synthesis of diversely substituted quaternary 1,4-benzodiazepin-2-ones and 1,4-benzodiazepine-2,5-diones
    Carlier, Paul R.
    Zhao, Hongwu
    MacQuarrie-Hunter, Stephanie L.
    DeGuzman, Joseph C.
    Hsu, Danny C.
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (47) : 15215 - 15220
  • [35] SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIPS OF 1-ALKOXYALKYL- AND 1-ARYLOXYALKYL-1,4-BENZODIAZEPIN-2-ONES
    LAMDAN, S
    GAOZZA, CH
    SICARDI, S
    IZQUIERD.JA
    JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (04) : 742 - &
  • [36] Novel access to 1,4-benzodiazepin-2-ones via the Buchwald reaction and application to the synthesis of novel heterocyclics
    Salome, Christophe
    Schmitt, Martine
    Bourguignon, Jean-Jacques
    TETRAHEDRON LETTERS, 2012, 53 (09) : 1033 - 1035
  • [37] NITRATION PRODUCTS OF SUBSTITUTED 1,3-DIHYDRO-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONES
    FRYER, RI
    GU, ZQ
    TODARO, L
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1991, 28 (05) : 1203 - 1208
  • [38] CONVENIENT SYNTHESIS OF 5-SUBSTITUTED 1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONES
    OGATA, M
    MATSUMOTO, H
    CHEMISTRY & INDUSTRY, 1976, (24) : 1067 - 1068
  • [39] STEREOCHEMISTRY OF ENZYMIC 3-HYDROXYLATION OF 1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONES
    CORBELLA, A
    GARIBOLDI, P
    JOMMI, G
    FORGIONE, A
    MARCUCCI, F
    MARTELLI, P
    MUSSINI, E
    MAURI, F
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1973, (19) : 721 - 722
  • [40] Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones
    Azuaje, Jhonny
    Perez-Rubio, Jose M.
    Yaziji, Vicente
    El Maatougui, Abdelaziz
    Carlos Gonzalez-Gomez, Jose
    Sanchez-Pedregal, Victor M.
    Navarro-Vazquez, Armando
    Masaguer, Christian F.
    Teijeira, Marta
    Sotelo, Eddy
    JOURNAL OF ORGANIC CHEMISTRY, 2015, 80 (03): : 1533 - 1549
12345