1,4-benzodiazepin-2-ones in medicinal chemistry

被引：41
|
作者：
Spencer, John [1 ]
Rathnam, Rajendra P. [1 ]
Chowdhry, Babur Z. [1 ]
机构：
[1] Univ Greenwich Medway, Sch Sci, Chatham ME4 4TB, Kent, England
来源：
FUTURE MEDICINAL CHEMISTRY | 2010年 / 2卷 / 09期
关键词：
RECEPTOR ANTAGONISTS; COMBINATORIAL SYNTHESIS; BIOLOGICAL EVALUATION; PRIVILEGED STRUCTURES; CCK2; ANTAGONISTS; HIGHLY POTENT; BENZODIAZEPINE; INHIBITORS; DERIVATIVES; NONPEPTIDE;
D O I：
10.4155/FMC.10.226
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
1,4-benzodiazepin-2-ones have applications in many areas of medicinal chemistry that are not restricted to 'classical' CNS treatments such as sedatives, epilepsy and muscle relaxants. We will describe selected examples of 1,4-benzodiazepin-2-ones in other areas of medicinal chemistry including uses as G-protein-coupled receptor antagonists, enzyme inhibitors and anticancer agents. Examples from our group will mainly show the use of palladacycle complexes of 1,4-benzodiazepin-2-ones as anticancer agents.
引用
收藏
页码：1441 / 1449
页数：9
相关论文
共 50 条
  • [1] HYDROXYLATION OF 1,4-BENZODIAZEPIN-2-ONES BY ACTINOMYCETES
    DAVIDENKO, TL
    ZABOLOTSKAIA, NN
    MILIENKO, NP
    ANDRONATI, SA
    KUZNETSOV, VD
    BOGATSKII, AV
    DOKLADY AKADEMII NAUK SSSR, 1984, 278 (04): : 878 - 881
  • [2] 3-SUBSTITUTED 1,4-BENZODIAZEPIN-2-ONES
    BELL, SC
    MCCAULLY, RJ
    GOCHMAN, C
    CHILDRESS, SJ
    GLUCKMAN, MI
    JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (03) : 457 - +
  • [3] CONFORMATION OF UNSYMMETRICALLY SUBSTITUTED 1,4-BENZODIAZEPIN-2-ONES
    SADEE, W
    SCHWANDT, HJ
    BEYER, KH
    ARCHIV DER PHARMAZIE, 1973, 306 (10) : 751 - 756
  • [4] GOLD(III) COMPLEXES OF SOME 1,4-BENZODIAZEPIN-2-ONES
    MINGHETTI, G
    FODDAI, C
    CARIATI, F
    GANADU, ML
    MANASSERO, M
    INORGANICA CHIMICA ACTA-LETTERS, 1982, 64 (05): : L235 - L236
  • [5] Synthesis of 3-substituted 1,4-benzodiazepin-2-ones
    Kim, K
    Folkman, SK
    Ellman, JA
    JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY, 1998, 9 (04) : 375 - 379
  • [6] BENZODIAZEPINES .12. SYNTHESIS OF 5-(2-PYRIDYL)-1,4-BENZODIAZEPIN-2-ONES AND 3-METHYL-1,4-BENZODIAZEPIN-2-ONES
    INABA, S
    ISHIZUMI, K
    OKAMOTO, T
    YAMAMOTO, H
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1975, 23 (12) : 3279 - 3282
  • [7] SYNTHESIS OF IMIDAZOLIDIN-4-ONES AND THEIR CONVERSION INTO 1,4-BENZODIAZEPIN-2-ONES
    HANNOUN, M
    ZINIC, M
    KOLBAH, D
    BLAZEVIC, N
    KAJFEZ, F
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 1981, 18 (05) : 963 - 965
  • [8] STEREOSELECTIVE INVITRO AROMATIC OXYGENATIONS OF CHIRAL 1,4-BENZODIAZEPIN-2-ONES
    RENDIC, S
    SUNJIC, V
    KAJFEZ, F
    BLAZEVIC, M
    HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1976, 357 (08): : 1051 - 1052
  • [9] Synthesis and biological evaluation of 1,4-benzodiazepin-2-ones with antitrypanosomal activity
    Spencer, John
    Rathnam, Rajendra P.
    Harvey, Alan L.
    Clements, Carol J.
    Clark, Rachel L.
    Barrett, Michael P.
    Wong, Pui Ee
    Male, Louise
    Coles, Simon J.
    Mackay, Simon P.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 19 (05) : 1802 - 1815
  • [10] FRAGMENTATION PATTERN OF 1,4-BENZODIAZEPIN-2-ONES UNDER ELECTRON IMPACT
    SADEE, W
    JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (03) : 475 - +
12345