Activin/Nodal signalling in stem cells

被引：134

作者：

Pauklin, Siim ^{[1
]}

Vallier, Ludovic ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Stem Cell Inst, Wellcome Trust Med Res Council, Anne McLaren Lab Regenerat Med, Cambridge CB2 0SZ, England

来源：

DEVELOPMENT | 2015年 / 142卷 / 04期

关键词：

Activin; Cell cycle; Differentiation; Nodal; Pluripotency; Stem cells; TGF-BETA; SELF-RENEWAL; INDUCED DIFFERENTIATION; MAINTAINS PLURIPOTENCY; FUNCTIONAL-ANALYSIS; REGULATORY NETWORK; NODAL EXPRESSION; MOUSE EMBRYOS; ZEBRAFISH; GENE;

D O I：

10.1242/dev.091769

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.

引用

页码：607 / 619

页数：13

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