Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin

被引：14

作者：

Pope, SN ^{[1
]}

Lee, IR ^{[1
]}

机构：

[1] Curtin Univ Technol, Sch Biomed Sci, Perth, WA 6845, Australia

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2005年 / 94卷 / 1-3期

关键词：

yeast two-hybrid; sex hormone-binding globulin; prostate;

D O I：

10.1016/j.jsbmb.2005.01.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast two-hybrid (Y2H) screening of a prostate cDNA library with the cDNA for sex hormone-binding globulin (SHBG) has been used to identify proteins through which SHBG may exert autocrine or paracrine effects on sex steroid target tissues. The library screen gave 230 positive interactions of which around 60 have been sequenced. Of the proteins identified to date from database (BLAST) searches of these sequences, SHBG is one of those occurring most frequently. Amongst the proteins of interest are the membrane-associated proteins flotillin-1 and PRV-1, the enzymes cathepsin D, kallikrein 4 and acid phosphatase, various metallothioneins and translation elongation factor 1 alpha. The significance of the interaction of SHBG with these proteins is discussed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：203 / 208

页数：6

共 50 条

[31] Identification of tuftelin- and amelogenin-interacting proteins using the yeast two-hybrid system
Paine, CT
Paine, ML
Snead, ML
CONNECTIVE TISSUE RESEARCH, 1998, 38 (1-4) : 257 - 267
[32] Lignans interfering with 5α-dihydrotestosterone binding to human sex hormone-binding globulin
Schöttner, M
Spiteller, G
Gansser, D
JOURNAL OF NATURAL PRODUCTS, 1998, 61 (01): : 119 - 121
[33] The yeast two-hybrid approach for identification of H-pylori VacA cytotoxin interacting proteins
Hennig, EE
Butruk, E
Ostrowski, J
GUT, 2001, 49 : A13 - A13
[34] Human sex hormone-binding globulin gene expression in transgenic mice
Jänne, M
Deol, HK
Power, SGA
Yee, SP
Hammond, GL
MOLECULAR ENDOCRINOLOGY, 1998, 12 (01) : 123 - 136
[35] Identification of espin-binding proteins using a yeast two-hybrid approach.
Chen, B
Bartles, JR
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 25A - 25A
[36] THE METABOLISM OF HUMAN SEX HORMONE-BINDING GLOBULIN IN THE RHESUS-MONKEY
LONGCOPE, C
TAST, J
DEVITO, WJ
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, 1992, 201 (02): : 219 - 222
[37] AN ENZYME-IMMUNOASSAY FOR HUMAN SEX HORMONE-BINDING GLOBULIN (SHBG)
HEUBNER, A
RUDE, S
JUCHEM, M
POLLOW, K
ACTA ENDOCRINOLOGICA, 1987, 114 : 139 - 139
[38] Identification of E47 binding proteins in human fetal kidney using the yeast two-hybrid system
Quaggin, SE
Li, K
Igarashi, P
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 1996, 7 (09): : A1772 - A1772
[39] Plasma variation of corticosteroid-binding globulin and sex hormone-binding globulin
Lewis, J. G.
Möpert, B.
Shand, B. I.
Doogue, M. P.
Soule, S. G.
Frampton, C. M.
Elder, P. A.
HORMONE AND METABOLIC RESEARCH, 2006, 38 (04) : 241 - 245
[40] Identification of Host Proteins Interacting with Toxoplasma gondii SAG1 by Yeast Two-Hybrid Assay
Lai, Meng-Yee
Abdul-Majid, Nazia
Lau, Yee-Ling
ACTA PARASITOLOGICA, 2019, 64 (03) : 575 - 581

← 1 2 3 4 5 →