White Blood Cell Count and Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention in the Contemporary Era Insights From the PARIS Study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry)

被引:37
|
作者
Shah, Binita [1 ,2 ]
Baber, Usman [3 ]
Pocock, Stuart J. [4 ]
Krucoff, Mitchell W. [5 ]
Ariti, Cono [4 ]
Gibson, C. Michael [6 ]
Steg, Philippe Gabriel [7 ]
Weisz, Giora [8 ]
Witzenbichler, Bernhard [9 ]
Henry, Timothy D. [10 ,11 ]
Kini, Annapoorna S. [3 ]
Stuckey, Thomas [12 ]
Cohen, David J. [13 ]
Iakovou, Ioannis [14 ]
Dangas, George [3 ]
Aquino, Melissa B. [3 ]
Sartori, Samantha [3 ]
Chieffo, Alaide [15 ]
Moliterno, David J. [16 ]
Colombo, Antonio [15 ]
Mehran, Roxana [3 ]
机构
[1] Manhattan VA Hosp, New York Harbor Hlth Care Syst, Dept Med Cardiol, New York, NY USA
[2] NYU, Sch Med, Dept Med Cardiol, New York, NY 10003 USA
[3] Icahn Sch Med Mt Sinai, Dept Med Cardiol, New York, NY 10029 USA
[4] London Sch Hyg & Trop Med, Med Stat, London, England
[5] Duke Univ, Sch Med, Dept Med Cardiol, Durham, NC USA
[6] Harvard Med Sch, Dept Med Cardiol, Cambridge, MA USA
[7] Hop Bichat Claude Bernard, Dept Med Cardiol, Paris, France
[8] Columbia Univ, Med Ctr, Dept Med Cardiol, New York, NY USA
[9] HELIOS Amper Klinikum, Dept Med Cardiol, Dachau, Germany
[10] Cedars Sinai Heart Inst, Dept Med Cardiol, Los Angeles, CA USA
[11] Univ Minnesota, Minneapolis Heart Inst Fdn, Dept Med Cardiol, Minneapolis, MN USA
[12] LeBauer Cardiovasc Res Fdn, Moses Cone Heart & Vasc Ctr, Dept Med Cardiol, Greensboro, NC USA
[13] Univ Missouri Kansas City, St Lukes Mid Amer Heart Inst, Dept Med Cardiol, Kansas City, MO USA
[14] Onassis Cardiac Surg Ctr, Dept Med Cardiol, Athens, Greece
[15] Osped San Raffaele, Dept Med Cardiol, Milan, Italy
[16] Univ Kentucky, Dept Med Cardiol, Lexington, KY USA
关键词
acute coronary syndrome; coronary artery disease; leukocytes; myocardial infarction; percutaneous coronary intervention; PLATELET-LEUKOCYTE INTERACTIONS; ACUTE MYOCARDIAL-INFARCTION; INTEGRIN MAC-1 CD11B/CD18; RANDOMIZED-TRIAL; ADHESION MOLECULES; ENDOTHELIAL-CELLS; ARTERY-DISEASE; ANGIOPLASTY; ATORVASTATIN; ASSOCIATION;
D O I
10.1161/CIRCINTERVENTIONS.117.004981
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background-Elevated white blood cell (WBC) count is associated with increased major adverse cardiovascular events (MACE) in the setting of acute coronary syndrome. The aim of this study was to evaluate whether similar associations persist in an all-comers population of patients undergoing percutaneous coronary intervention in the contemporary era. Methods and Results-In the multicenter, prospective, observational PARIS study (Patterns of Non-Adherence to Anti-Platelet Regimens in Stented Patients Registry), 4222 patients who underwent percutaneous coronary intervention in the United States and Europe between July 1, 2009, and December 2, 2010, were evaluated. The associations between baseline WBC and MACE (composite of cardiac death, stent thrombosis, spontaneous myocardial infarction, or target lesion revascularization) at 24-month follow-up were analyzed using multivariable Cox regression. Patients with higher WBC were more often younger, smokers, and with less comorbid risk factors compared with those with lower WBC. After adjustment for baseline and procedural characteristics, WBC remained independently associated with MACE (hazard ratio [HR] per 103 cells/L increase, 1.05 [95% confidence intervals (CI), 1.02-1.09]; P=0.001), cardiac death (HR, 1.10 [95% CI, 1.05-1.17]; P<0.001), and clinically indicated target revascularization (HR, 1.04 [95% CI, 1.00-1.09]; P=0.03) but not stent thrombosis (HR, 1.07 [95% CI, 0.99-1.16]; P=0.10) or spontaneous myocardial infarction (HR, 1.03 [95% CI, 0.97-1.09]; P=0.29). The association between WBC and MACE was consistent in acute coronary syndrome and non-acute coronary syndrome presentations (interaction P=0.15). Conclusions-Increased WBC is an independent predictor of MACE after percutaneous coronary intervention in a contemporary all-comers cohort. Further studies to delineate the underlying pathophysiologic role of elevated WBC across a spectrum of coronary artery disease presentations are warranted.
引用
收藏
页数:14
相关论文
共 26 条
  • [21] The Combinations of the Patterns of Non-adherence to Anti-platelet Regimen in Stented Patients (PARIS) and Coronary Revascularization Demonstrating Outcome Study in Kyoto (CREDO-Kyoto) Thrombotic and Bleeding Risk Scores on Clinical Outcomes in Patients with Acute Myocardial Infarction
    Yamashita, Daichi
    Saito, Yuichi
    Sato, Takanori
    Matsumoto, Tadahiro
    Suzuki, Sakuramaru
    Saito, Kan
    Wakabayashi, Shinichi
    Kitahara, Hideki
    Sano, Koichi
    Kobayashi, Yoshio
    INTERNAL MEDICINE, 2024, 63 (04) : 475 - 480
  • [22] Prognostic Value of the Patterns of Non-adherence to Antiplatelet Regimen in Stented Patients (PARIS) Bleeding Risk Score for Long Term All-cause and Cardiac Mortalities After Percutaneous Coronary Intervention
    Akama, Joh
    Shimizu, Takeshi
    Ando, Takuya
    Anzai, Fumiya
    Muto, Yuuki
    Kimishima, Yusuke
    Kiko, Takatoyo
    Yoshihisa, Akiomi
    Yamaki, Takayoshi
    Kunii, Hiroyuki
    Nakazato, Kazuhiko
    Ishida, Takafumi
    Takeishi, Yasuchika
    CIRCULATION, 2020, 142
  • [23] Impact of baseline hemoglobin level and white blood cell count in real-world patients undergoing contemporary percutaneous coronary intervention: insights from the GLOBAL LEADER study
    Chichareon, P.
    Modolo, R.
    Tomaniak, M.
    Kogame, N.
    Fontos, G.
    Lantelme, P.
    Barraud, P.
    Hamm, C.
    Steg, G.
    Juni, P.
    Vranckx, P.
    Valgimigli, M.
    Windecker, S.
    Onuma, Y.
    Serruys, P. W.
    EUROPEAN HEART JOURNAL, 2019, 40 : 1958 - 1958
  • [24] Impact of white blood cell count on clinical outcomes in patients treated with aspirin-free ticagrelor monotherapy after percutaneous coronary intervention: insights from the GLOBAL LEADERS trial
    Ono, Masafumi
    Tomaniak, Mariusz
    Koenig, Wolfgang
    Khamis, Ramzi
    de Silva, Ranil
    Chichareon, Ply
    Kawashima, Hideyuki
    Hara, Hironori
    Gao, Chao
    Wang, Rutao
    Huber, Kurt
    Vrolix, Mathias
    Jasionowicz, Pawel
    Wykrzykowska, Joanna J.
    Piek, Jan J.
    Juni, Peter
    Hamm, Christian
    Steg, Philippe Gabriel
    Windecker, Stephan
    Onuma, Yoshinobu
    Storey, Robert F.
    Serruys, Patrick W.
    EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY, 2022, 8 (01) : 39 - 47
  • [25] Association of Glycosylated Hemoglobin with Long-Term Adverse Cardiac Events after Percutaneous Coronary Intervention in Non Diabetes and Controlled Diabetes Patients: An Observational Study from the Korean COACT Registry
    Park, Ha-Wook
    Her, Sung-Ho
    Jung, Jin
    Chun, Hyunji
    Chung, Wook-Sung
    LIFE-BASEL, 2022, 12 (11):
  • [26] Impact of contrast-induced acute kidney injury on long-term major adverse cardiovascular events and kidney function after percutaneous coronary intervention: insights from a territory-wide cohort study in Hong Kong
    Ng, Andrew Kei-Yan
    Ng, Pauline Yeung
    Ip, April
    Lam, Lap-Tin
    Ling, Ian Wood-Hay
    Wong, Alan Shing-Lung
    Yap, Desmond Yat-Hin
    Siu, Chung-Wah
    CLINICAL KIDNEY JOURNAL, 2022, 15 (02) : 338 - 346