Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

被引：3
|
作者：
Jeon, Bo-Ra [1 ]
Irfan, Muhammad [1 ]
Lee, Seung Eun [2 ]
Lee, Jeong Hoon [2 ]
Rhee, Man Hee [1 ]
机构：
[1] Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea
[2] Natl Inst Hort & Herbal Sci NIHHS, Dept Herbal Crop Res, Eumseong 27709, South Korea
来源：
CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2022年 / 28卷 / 09期
基金：
新加坡国家研究基金会;
关键词：
antiplatelet; ethnomedicine; integrin alpha(IIb)beta(3); mitogen-activated protein kinase; Rumex acetosella L; CARDIOVASCULAR-DISEASE; TRADITIONAL MEDICINE; THROMBUS FORMATION; ACTIVATION; ANTIPLATELET; GINSENG; PHOSPHORYLATION; GINSENOSIDES;
D O I：
10.1007/s11655-021-2873-0
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Objective: To examine the antiplatelet and antithrombotic activity of Rumex acetosella extract. Methods: Standard light aggregometry was used for platelet aggregation, intracellular calcium mobilization assessed using Fura-2/AM, granule secretion (ATP release) by luminometer, and fibrinogen binding to integrin alpha(IIb)beta(3) detected using flow cytometry. Western blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt signaling. Results: Rumex acetosella displayed the ability to inhibit platelet aggregation, calcium mobilization, granule secretion, and fibrinogen binding to integrin alpha(IIb)beta(3). Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation (all P<0.01). Conclusion: Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling, and it may protect against the development of platelet-related cardiovascular diseases.
引用
收藏
页码：802 / 808
页数：7
相关论文
共 50 条
  • [31] Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
    Riobó, NA
    Lu, K
    Ai, XB
    Haines, GM
    Emerson, CP
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (12) : 4505 - 4510
  • [32] SYK is upstream of phosphoinositide 3-kinase in BCR signaling.
    Beitz, LO
    Fruman, DA
    Ishial, M
    Kurosaki, T
    Cantley, LC
    Scharenberg, AM
    ARTHRITIS AND RHEUMATISM, 1999, 42 (09): : S259 - S259
  • [33] Effects of ghrelin and insulin on phosphoinositide 3-kinase signaling in the hypothalamus
    Tylee, TS
    Cummings, DE
    DIABETES, 2005, 54 : A445 - A446
  • [34] Phosphoinositide 3-kinase signaling in the cellular response to oxidative stress
    Barthel, A
    Klotz, LO
    BIOLOGICAL CHEMISTRY, 2005, 386 (03) : 207 - 216
  • [35] Phosphoinositide 3-Kinase Mediated Signaling in Lobster Olfactory Transduction
    Corey, Elizabeth A.
    Pezier, Adeline
    Bobkov, Yuriy V.
    Ache, Barry W.
    CHEMICAL SENSES, 2008, 33 (08) : S123 - S123
  • [36] Phosphoinositide 3-Kinase/Akt Signaling and Redox Metabolism in Cancer
    Koundouros, Nikos
    Poulogiannis, George
    FRONTIERS IN ONCOLOGY, 2018, 8
  • [37] Signaling via phosphoinositide 3-kinase.
    Cantley, L
    Toker, A
    Rameh, L
    FASEB JOURNAL, 1996, 10 (06): : 1602 - 1602
  • [38] Phosphoinositide lipid phosphatases: Natural regulators of phosphoinositide 3-kinase signaling in T lymphocytes
    Harris, Stephanie J.
    Parry, Richard V.
    Westwick, John
    Ward, Stephen G.
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (05) : 2465 - 2469
  • [39] Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function
    Pang, JH
    Kraemer, A
    Stehbens, SJ
    Frame, MC
    Yap, AS
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (04) : 3043 - 3050
  • [40] Role of phosphoinositide 3-kinase in platelet signalling and regulation of thrombus formation
    Saeed, S. A.
    Manzoor, I.
    Hussain, S.
    Ahmad, S.
    Gowani, S. A. S.
    Thebo, U. A.
    Zaffar, N.
    Waqar, M. A.
    JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2007, 29 (04): : 383 - 389
12345