Rumex acetosella Inhibits Platelet Function via Impaired MAPK and Phosphoinositide 3-Kinase Signaling

被引：3

作者：

Jeon, Bo-Ra ^{[1
]}

Irfan, Muhammad ^{[1
]}

Lee, Seung Eun ^{[2
]}

Lee, Jeong Hoon ^{[2
]}

Rhee, Man Hee ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Lab Physiol & Cell Signaling, Daegu 41566, South Korea

[2] Natl Inst Hort & Herbal Sci NIHHS, Dept Herbal Crop Res, Eumseong 27709, South Korea

来源：

CHINESE JOURNAL OF INTEGRATIVE MEDICINE | 2022年 / 28卷 / 09期

基金：

新加坡国家研究基金会;

关键词：

antiplatelet; ethnomedicine; integrin alpha(IIb)beta(3); mitogen-activated protein kinase; Rumex acetosella L; CARDIOVASCULAR-DISEASE; TRADITIONAL MEDICINE; THROMBUS FORMATION; ACTIVATION; ANTIPLATELET; GINSENG; PHOSPHORYLATION; GINSENOSIDES;

D O I：

10.1007/s11655-021-2873-0

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Objective: To examine the antiplatelet and antithrombotic activity of Rumex acetosella extract. Methods: Standard light aggregometry was used for platelet aggregation, intracellular calcium mobilization assessed using Fura-2/AM, granule secretion (ATP release) by luminometer, and fibrinogen binding to integrin alpha(IIb)beta(3) detected using flow cytometry. Western blotting is carried out to determine the phosphorylation of mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/Akt signaling. Results: Rumex acetosella displayed the ability to inhibit platelet aggregation, calcium mobilization, granule secretion, and fibrinogen binding to integrin alpha(IIb)beta(3). Rumex acetosella has also down-regulated MAPK and PI3K/Akt phosphorylation (all P<0.01). Conclusion: Rumex acetosella extract exhibits antiplatelet activity via modulating GPVI signaling, and it may protect against the development of platelet-related cardiovascular diseases.

引用

页码：802 / 808

页数：7

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