Maternal HIV infection influences the microbiome of HIV-uninfected infants

被引：85

作者：

Bender, Jeffrey M. ^{[1
,2
]}

Li, Fan ^{[1
]}

Martelly, Shoria ^{[3
]}

Byrt, Erin ^{[4
,5
]}

Rouzier, Vanessa ^{[3
]}

Leo, Marguerite ^{[3
]}

Tobin, Nicole ^{[1
]}

Pannaraj, Pia S. ^{[1
]}

Adisetiyo, Helty ^{[1
]}

Rollie, Adrienne ^{[1
]}

Santiskulvong, Chintda ^{[1
]}

Wang, Shaun ^{[4
]}

Autran, Chloe ^{[6
]}

Bode, Lars ^{[6
]}

Fitzgerald, Daniel ^{[5
]}

Kuhn, Louise ^{[4
]}

Aldrovandi, Grace M. ^{[1
,2
]}

机构：

[1] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[3] GHESKIO Ctr, Haitian Grp Study Kaposis Sarcoma & Opportunist I, Port Au Prince 15727, Ouest, Haiti

[4] Columbia Univ, Dept Epidemiol & Biostat, New York, NY 10032 USA

[5] Weill Cornell Med Coll, Ctr Global Hlth, New York, NY 10065 USA

[6] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 349期

关键词：

HUMAN-MILK OLIGOSACCHARIDES; INCREASED RISK; CHILDREN BORN; GUT MICROBIOME; BREAST-MILK; MORTALITY; MOTHERS; DISEASE; PROBIOTICS; MORBIDITY;

D O I：

10.1126/scitranslmed.aaf5103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.

引用

页数：12

共 50 条

[21] Co-trimoxazole prophylaxis may not be necessary in breast feeding HIV-exposed, HIV-uninfected infants
不详
ARCHIVES OF DISEASE IN CHILDHOOD, 2020, 105 (01) : 3 - 3
[22] Progressive Multifocal Leukoencephalopathy in HIV-Uninfected Individuals
Deanna Saylor
Arun Venkatesan
Current Infectious Disease Reports, 2016, 18
[23] Progressive Multifocal Leukoencephalopathy in HIV-Uninfected Individuals
Saylor, Deanna
Venkatesan, Arun
CURRENT INFECTIOUS DISEASE REPORTS, 2016, 18 (11)
[24] Maternal HIV disclosure to young HIV-uninfected children: an evaluation of a family-centred intervention in South Africa
Rochat, Tamsen J.
Arteche, Adriane X.
Stein, Alan
Mkwanazi, Ntombizodumo
Bland, Ruth M.
AIDS, 2014, 28 : S331 - S341
[25] Maternal HIV Infection and Antibody Responses Against Vaccine-Preventable Diseases in Uninfected Infants
Jones, Christine E.
Naidoo, Shalena
De Beer, Corena
Esser, Monika
Kampmann, Beate
Hesseling, Anneke C.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (06): : 576 - 584
[26] Longitudinal anthropometric changes in HIV-infected and HIV-uninfected men
Brown, Todd
Wang, Zhaojie
Chu, Haito
Palella, Frank J.
Kingsley, Lawrence
Witt, Mallory D.
Dobs, Adrian S.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2006, 43 (03) : 356 - 362
[27] Tonsil histopathology in HIV-infected versus HIV-uninfected adults
Essa, Ridwaan
Maharaj, Shivesh
Hari, Kapila
Motakef, Shahpar
SOUTHERN AFRICAN JOURNAL OF HIV MEDICINE, 2019, 20 (01)
[28] Strategies for Preventing HIV Infection Among HIV-Uninfected Women Attempting Conception with HIV-Infected Men - United States
Kawwass, Jennifer F.
Smith, Dawn K.
Kissin, Dmitry M.
Haddad, Lisa B.
Boulet, Sheree L.
Sunderam, Saswati
Jamieson, Denise J.
MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2017, 66 (21): : 554 - 557
[29] Left ventricular diastolic dysfunction in HIV-uninfected infants exposed in utero to antiretroviral therapy
Lipshultz, Steven E.
Sasaki, Nao
Thompson, Bruce
Eidem, Benjamin W.
Cheng, Irene
Colan, Steven D.
O'Brien, Sharon E.
Amdani, Shahnawaz
Shearer, William T.
Orav, Endel John
Miller, Tracie L.
Wilkinson, James D.
AIDS, 2020, 34 (04) : 529 - 537
[30] Latent tuberculosis infection and associated risk factors among people living with HIV and HIV-uninfected individuals in Lithuania
Matulyte, E.
Kancauskiene, Z.
Kausas, A.
Urboniene, J.
Lipnickiene, V.
Razmiene, I.
Kopeykiniene, J.
Jonaityte, B.
Eimutiene, A.
Arstikaitiene, G.
Lisinskaite, A.
Gudaitis, T.
Raudonis, S.
Danila, E.
Costagliola, D.
Matulionyte, R.
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2022, 25 : 124 - 126

← 1 2 3 4 5 →