Maternal HIV infection influences the microbiome of HIV-uninfected infants

被引：85

作者：

Bender, Jeffrey M. ^{[1
,2
]}

Li, Fan ^{[1
]}

Martelly, Shoria ^{[3
]}

Byrt, Erin ^{[4
,5
]}

Rouzier, Vanessa ^{[3
]}

Leo, Marguerite ^{[3
]}

Tobin, Nicole ^{[1
]}

Pannaraj, Pia S. ^{[1
]}

Adisetiyo, Helty ^{[1
]}

Rollie, Adrienne ^{[1
]}

Santiskulvong, Chintda ^{[1
]}

Wang, Shaun ^{[4
]}

Autran, Chloe ^{[6
]}

Bode, Lars ^{[6
]}

Fitzgerald, Daniel ^{[5
]}

Kuhn, Louise ^{[4
]}

Aldrovandi, Grace M. ^{[1
,2
]}

机构：

[1] Childrens Hosp Los Angeles, Los Angeles, CA 90027 USA

[2] Univ Southern Calif, Keck Sch Med, Dept Pediat, Los Angeles, CA 90033 USA

[3] GHESKIO Ctr, Haitian Grp Study Kaposis Sarcoma & Opportunist I, Port Au Prince 15727, Ouest, Haiti

[4] Columbia Univ, Dept Epidemiol & Biostat, New York, NY 10032 USA

[5] Weill Cornell Med Coll, Ctr Global Hlth, New York, NY 10065 USA

[6] Univ Calif San Diego, Dept Pediat, La Jolla, CA 92093 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 349期

关键词：

HUMAN-MILK OLIGOSACCHARIDES; INCREASED RISK; CHILDREN BORN; GUT MICROBIOME; BREAST-MILK; MORTALITY; MOTHERS; DISEASE; PROBIOTICS; MORBIDITY;

D O I：

10.1126/scitranslmed.aaf5103

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.

引用

页数：12

共 50 条

[1] Maternal HIV infection and other factors associated with growth outcomes of HIV-uninfected infants in Entebbe, Uganda
Muhangi, Lawrence
Lule, Swaib A.
Mpairwe, Harriet
Ndibazza, Juliet
Kizza, Moses
Nampijja, Margaret
Nakazibwe, Esther
Kihembo, Macklyn
Elliott, Alison M.
Webb, Emily L.
PUBLIC HEALTH NUTRITION, 2013, 16 (09) : 1548 - 1557
[2] Maternal HIV Infection and Antibody Responses in Uninfected Infants
de Souza, Thais Louvain
de Souza Campos Fernandes, Regina Celia
Medina-Acosta, Enrique
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2011, 305 (19): : 1964 - 1964
[3] In-utero exposure to maternal HIV infection alters T-cell immune responses to vaccination in HIV-uninfected infants
Kidzeru, Elvis B.
Hesseling, Anneke C.
Passmore, Jo-Ann S.
Myer, Landon
Gamieldien, Hoyam
Tchakoute, Christophe Toukam
Gray, Clive M.
Sodora, Donald L.
Jaspan, Heather B.
AIDS, 2014, 28 (10) : 1421 - 1430
[4] Commentary: Beyond Prevention of Vertical HIV TransmissionImproving Outcomes of HIV-uninfected Infants Born to Mothers With HIV Infection
Siberry, George K.
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2018, 37 (03) : 245 - 245
[5] Perinatal antiretroviral treatment and hematopoiesis in HIV-uninfected infants
Le Chenadec, J
Mayaux, MJ
Guihenneuc-Jouyaux, C
Blanche, S
AIDS, 2003, 17 (14) : 2053 - 2061
[6] Placental pathology in HIV infection at term: a comparison with HIV-uninfected women
Kalk, Emma
Schubert, Pawel
Bettinger, Julie A.
Cotton, Mark F.
Esser, Monika
Slogrove, Amy
Wright, Colleen A.
TROPICAL MEDICINE & INTERNATIONAL HEALTH, 2017, 22 (05) : 604 - 613
[7] Determinants of growth in HIV-exposed and HIV-uninfected infants in the Kabeho Study
Lane, Charlotte E.
Bobrow, Emily A.
Ndatimana, Diuedonne
Ndayisaba, Gilles F.
Adair, Linda S.
MATERNAL AND CHILD NUTRITION, 2019, 15 (03):
[8] Anthropometric Parameters of HIV-Infected and HIV-Uninfected Mothers and their Premature Infants
Fouche, Carike
Van Niekerk, Evette
du Plessis, Lisanne Monica
JOURNAL OF TROPICAL PEDIATRICS, 2018, 64 (04) : 255 - 261
[9] CMV pneumonia in HIV-infected and HIV-uninfected infants: a neglected disease?
Gie, Robert P.
Goussard, Pierre
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, 2017, 21 (12) : 1209 - 1210
[10] Maternal HIV Infection Alters Antimicrobial Immunity in Exposed and Uninfected Infants
Marchant, Arnaud
Amenyogbe, Nelly
Kollmann, Tobias R.
Goetghebuer, Tessa
PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2020, 39 (05) : E47 - E48

← 1 2 3 4 5 →