Selection of resistance mutations in pregnant women receiving zidovudine and lamivudine to prevent HIV perinatal transmission

被引：15
|
作者：
Giuliano, M
Palmisano, L
Galluzzo, CM
Amici, R
Germinario, E
Okong, P
Kituuka, P
Mmirro, F
Magoni, M
Vella, S
机构：
[1] Ist Super Sanita, Virol Lab, I-00161 Rome, Italy
[2] St Francis Nsambya Hosp, Kampala, Uganda
[3] Mulago Hosp, Kampala, Uganda
来源：
AIDS | 2003年 / 17卷 / 10期
关键词：
D O I：
10.1097/00002030-200307040-00022
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two zidovudine/lamivudine regimens for the prevention of HIV perinatal transmission were studied for the selection of resistance mutations. The M184V mutation was detected one week after delivery in six out of fifty women (12%) who received the regimen prepartum, intrapartum and postpartum, and was no longer present 3 months later. No nucleoside reverse transcriptase inhibitor resistance-associated mutations were detected in 50 women who received zidovudine/lamivudine intrapartum and postpartum only. No association with the risk of perinatal transmission was found.
引用
收藏
页码：1570 / 1572
页数：3
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