Functionalized azabicycloalkane amino acids by nitrone 1,3-dipolar intramolecular cycloaddition

被引：36
|
作者：
Manzoni, L
Arosio, D
Belvisi, L
Bracci, A
Colombo, M
Invernizzi, D
Scolastico, C
机构：
[1] CNR, ISTM, I-20133 Milan, Italy
[2] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy
[3] Ctr Interdisciplinare Studi Biomol & Applicaz Ind, CISI, I-20133 Milan, Italy
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 70卷 / 10期
关键词：
D O I：
10.1021/jo0500683
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and operationally simple method for the synthesis of functionalized azaoxobicyclo[X.3.0]alkane amino acids has been devised. The key step is an intramolecular nitrone cycloaddition on 5-allyl- or 5-homoallylproline that was found to be completely regio- and stereoselective.
引用
收藏
页码：4124 / 4132
页数：9
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