Treatment of Primary CNS Lymphoma With High-Dose Methotrexate in Immunocompetent Pediatric Patients

被引：15

作者：

Shah, Amish C. ^{[1
]}

Kelly, David R. ^{[2
]}

Nabors, L. Burt ^{[3
]}

Oakes, W. Jerry ^{[4
]}

Hilliard, Lee M. ^{[5
]}

Reddy, Alyssa T. ^{[3
,4
,5
]}

机构：

[1] Childrens Hosp Philadelphia, Dept Pediat, Philadelphia, PA 19104 USA

[2] Univ Alabama Birmingham, Dept Pathol, Sch Med, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Neurol, Sch Med, Birmingham, AL 35294 USA

[4] Univ Alabama Birmingham, Sch Med, Dept Surg, Birmingham, AL 35294 USA

[5] Univ Alabama Birmingham, Sch Med, Dept Pediat, Birmingham, AL USA

来源：

PEDIATRIC BLOOD & CANCER | 2010年 / 55卷 / 06期

关键词：

anaplastic large cell lymphoma; diffuse large B-cell lymphoma; methotrexate; primary central nervous system lymphoma; CENTRAL-NERVOUS-SYSTEM; LONG-TERM SURVIVAL; THERAPEUTIC MANAGEMENT; EPIDEMIOLOGY;

D O I：

10.1002/pbc.22752

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report two cases of primary CNS lymphoma (PCNSL) treated with high-close methotrexate. Though standard adult treatment of PCNSL incorporates whole-brain radiotherapy, the literature suggests it may be possible to delay or avoid radiotherapy and the associated increased risk of neurologic sequelae in pediatric patients. Studies in adults indicate methotrexate therapy can be effective against PCNSL and has advantages over the current standard of treatment. Both patients have no evidence of disease 9 and 7 years after treatment, suggesting high-close methotrexate may lead to disease control in pediatric patients with PCNSL while avoiding the effects of radiotherapy. Pediatr Blood Cancer. 2010;55:1227-1230. (C) 2010 Wiley-Liss, Inc.

引用

页码：1227 / 1230

页数：4

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