Expression of putative markers of pluripotency in equine embryonic and adult tissues

被引：10

作者：

Esteves, Cristina L. ^{[1
]}

Sharma, Ruchi ^{[1
]}

Dawson, Lucy ^{[1
]}

Taylor, Sarah E. ^{[1
]}

Pearson, Gemma ^{[1
]}

Keen, John A. ^{[1
]}

McDonald, Kieran ^{[2
]}

Aurich, Christine ^{[3
]}

Donadeu, F. Xavier ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Vet Studies, Roslin Inst & Royal Dick, Edinburgh EH25 9RG, Midlothian, Scotland

[2] Edinburgh Technopole, Biobest Labs, Edinburgh EH26 0PY, Midlothian, Scotland

[3] Univ Vet Sci, Artificial Inseminat & Embryo Transfer, A-1210 Vienna, Austria

来源：

VETERINARY JOURNAL | 2014年 / 202卷 / 03期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Equine; Induced pluripotent stem cells; Mesenchymal stem/stromal cells; MESENCHYMAL STEM-CELLS; ADIPOSE-TISSUE; BONE-MARROW; NEURONS;

D O I：

10.1016/j.tvjl.2014.08.026

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Expression of several putative markers of pluripotency (OCT4, SOX2, NANOG, LIN28A, REX1, DNMT3B and TERT) was examined in a range of equine tissues, including early embryos, induced pluripotent stem cells (iPSCs), testis, adipose- and bone marrow-derived mesenchymal stromal cells (MSCs), and keratinocytes. Transcript levels of all markers were highest in embryos and iPSCs and, except for SOX2, were very low or undetectable in keratinocytes. Mean expression levels of all markers were lower in testis than in embryos or iPSCs and, except for DNMT3B, were higher in testis than in MSCs. Expression of OCT4, NANOG and DNMT3B, but not the other markers, was detected in MSCs. Of all markers analysed, only LIN28A, REX1 and TERT were associated exclusively with pluripotent cells in the horse. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：533 / 535

页数：3

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