Discovery and characterization of PI3Kbeta isoform-selective inhibitors

被引：0
|
作者：
Virone-Oddos, A. [1 ]
Halley, F. [1 ]
Delorme, C. [1 ]
Bonnevaux, H. [1 ]
Nicolas, J. P. [1 ]
Karlsson, A. [1 ]
Abecassis, P. Y. [1 ]
Vincent, L. [1 ]
Lengauer, C. [1 ]
机构：
[1] Sanofi Aventis R&D, Oncol Drug Discovery & Preclin Dev, Vitry Sur Seine, France
来源：
EJC SUPPLEMENTS | 2010年 / 8卷 / 07期
关键词：
D O I：
10.1016/S1359-6349(10)71820-6
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：43 / 43
页数：1
相关论文
共 50 条
  • [1] PI3K Isoform-Selective Inhibitors in Cancer
    Duncan, Leslie
    Shay, Chloe
    Teng, Yong
    [J]. SINGLE-CELL SEQUENCING AND METHYLATION: METHODS AND CLINICAL APPLICATIONS, 2020, 1255 : 165 - 173
  • [2] Structure-Based Approach To Selective PI3Kbeta Inihibition
    Bertrand, Thomas
    Marquette, Jean-Pierre
    Karlsson, Andreas
    Michot, Nadine
    Virone-Oddos, Angela
    Halley, Frank
    [J]. ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, 2012, 68 : S26 - S26
  • [3] Isoform-Selective PI3K Inhibitors for Various Diseases
    Bheemanaboina, Rammohan R. Y.
    [J]. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2020, 20 (12) : 1074 - 1092
  • [4] Discovery and characterization of RLY-2608: The first allosteric, mutant, and isoform-selective inhibitor of PI3Kα
    Pazolli, Ermira
    Kipp, Randy
    Boezio, Alessandro
    Gunaydin, Hakan
    Iskandar, Amanda
    Zubrowski, Matthew
    Williams, Bret
    Shortsleeves, Kelley
    Larivee, Alexandre
    McLean, Tom
    Michelsen, Klaus
    Zeng, Hongtao
    LaRochelle, Jonathan
    Manna, Joe
    DiPietro, Lucian
    Mader, Mary
    Bennet, Bindu
    Wilbur, Jeremy
    Wang, Qi
    Pierce, Levi
    Martin, Iain
    Watters, James
    Fortin, Pascal
    Bergstrom, Donald
    [J]. MOLECULAR CANCER THERAPEUTICS, 2021, 20 (12)
  • [5] Isoform-selective histone deacetylase inhibitors
    Bieliauskas, Anton V.
    Pflum, Mary Kay H.
    [J]. CHEMICAL SOCIETY REVIEWS, 2008, 37 (07) : 1402 - 1413
  • [6] Isoform-selective histone deacetylase inhibitors
    Itoh, Yukihiro
    Suzuki, Takayoshi
    Miyata, Naoki
    [J]. CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (06) : 529 - 544
  • [7] Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase PI3Kα
    Nacht, Mariana
    Qiao, Lixin
    Sheets, Michael P.
    St. Martin, Thia
    Labenski, Matthew
    Mazdiyasni, Hormoz
    Karp, Russell
    Zhu, Zhendong
    Chaturvedi, Prasoon
    Bhavsar, Deepa
    Niu, Deqiang
    Westlin, William
    Petter, Russell C.
    Medikonda, Aravind Prasad
    Singh, Juswinder
    [J]. JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (03) : 712 - 721
  • [8] Stromal PI3Kbeta regulates breast tumor cell invasion
    Graff, R.
    Jakubik, C.
    Haimowitz, A. J.
    Sidoli, S.
    Gamble, M. J.
    Bresnick, A. R.
    Backer, J. M.
    [J]. MOLECULAR BIOLOGY OF THE CELL, 2023, 34 (02) : 985 - 986
  • [9] Improving the Armamentarium of PI3K Inhibitors with Isoform-Selective Agents: A new Light in the Darkness
    Rodon, Jordi
    Tabernero, Josep
    [J]. CANCER DISCOVERY, 2017, 7 (07) : 666 - 669
  • [10] PI3Kbeta regulates macropinocytosis in PTEN-null tumor cells
    Salloum, Gilbert
    Jakubik, Charles
    Bresnick, Anne R.
    Backer, Jonathan M.
    [J]. CANCER RESEARCH, 2019, 79 (13)
12345