Advanced laryngeal carcinoma: Surgical and non-surgical management options

In this article advanced laryngeal carcinoma is defined as clinical stage III and clinical stage IV malignant tumors arising from the laryngeal epithelium. This advanced stage depends on tumor size: presence of neck disease, or both (Box 1) [1]. A further elaboration of the definition would include the term "anaplastic or undifferentiated" in the overall description. According to one study. these tumors account for 46.03% of all squamous cell cancers that Occur in the larynx [2] and therefore 0.46% of all malignancies in humans (3).