Di(n-butyl) phthalate exposure impairs meiotic competence and development of mouse oocyte

被引：34
|
作者：
Li, Fei-Ping [1 ,2 ,3 ,4 ]
Zhou, Jie-Long [2 ]
Guo, Ai-Wei [2 ]
Liu, Yu [1 ,5 ]
Zhang, Fei [3 ,6 ]
Xu, Bai-Hui [1 ,3 ]
Liu, Rui [3 ,6 ]
Wang, Ya-Long [1 ,3 ]
Chen, Ming-Huang [3 ,6 ]
Lin, Yan-Hong [3 ,7 ]
He, Shu-Wen [1 ,3 ]
Liao, Bao-Qiong [1 ,3 ,8 ]
Fu, Xian-Pei [1 ,3 ]
Wang, Hai-Long [1 ,3 ]
机构：
[1] Xiamen Univ, Organ Transplantat Inst, Med Coll, Xiamen, Fujian, Peoples R China
[2] Southwest Forestry Univ, Coll Life Sci, Kunming, Yunnan, Peoples R China
[3] Fujian Key Lab Organ & Tissue Regenerat, Xiamen, Fujian, Peoples R China
[4] Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu Res Base Giant Panda Breeding, Chengdu, Sichuan, Peoples R China
[5] Guangxi Univ, Med Coll, Nanning, Guangxi, Peoples R China
[6] Xiamen Univ, Zhongshan Hosp, Dept Gynaecol & Obstet, Xiamen, Fujian, Peoples R China
[7] Fujian Med Univ, Dept Gynecol, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China
[8] Xiamen Univ, Dept Gynaecol & Obstet, Dongfang Affiliated Hosp, Fuzhou, Fujian, Peoples R China
来源：
ENVIRONMENTAL POLLUTION | 2019年 / 246卷
基金：
中国国家自然科学基金;
关键词：
Mice oocyte; Meiosis; Dibutyl phthalate; Spindle; Cytoskeletons; CELL APOPTOSIS; CUMULUS CELLS; MATURATION; ESTERS; DISRUPTION; INDUCTION; QUALITY; TESTES;
D O I：
10.1016/j.envpol.2018.12.077
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Di(n-butyl) phthalate (DBP) is extensively used in industrial applications as plasticizer and stabilizer and its presence in the environment may present health risks for human. Previous studies have demonstrated its mutagenic, teratogenic, and carcinogenic ability. However, its effect on mammalian oocyte maturation remains unknown. In this study, we examined the effect of DBP on oocyte maturation both in vitro and in vivo. Our results showed that DBP could significantly reduce mice oocyte germinal vesicle breakdown (GVBD) and polar body extrusion (PBE) rates. In addition, oocyte cytoskeleton was damaged and cortical granule-free domains (CGFDs) were also disrupted. Finally, DBP induced early apoptosis of oocyte and granulosa cells (GCs). Collectively, these data demonstrate that DBP could reduce meiosis competence and mouse oocyte development. (C) 2018 Published by Elsevier Ltd.
引用
收藏
页码：597 / 607
页数：11
相关论文
共 50 条
  • [41] Secondary Metabolites of Di-n-butyl phthalate (DnBP) and Di-iso-butyl phthalate (DiBP) in Urine as Valuable Biomarkers of Exposure
    Koch, H. M.
    Kaefferlein, H.
    Zur, Nieden A.
    Bruening, T.
    EPIDEMIOLOGY, 2008, 19 (06) : S281 - S281
  • [42] n-Butyl Benzyl Phthalate Exposure Promotes Lesion Survival in a Murine Endometriosis Model
    Sharma, Pooja
    Lee, Jo-Yu Lynn
    Tsai, Eing-Mei
    Chang, Yu
    Suen, Jau-Ling
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2021, 18 (07)
  • [43] Effect of di(n-butyl) phthalate on the blood-testis barrier during puberty onset
    Molele, Reneilwe A.
    Zakariah, Musa
    Ibrahim, Mohammed I. A.
    Mahdy, Mohamed A. A.
    Fosgate, Geoffrey T.
    Brown, Geoffrey
    ANATOMIA HISTOLOGIA EMBRYOLOGIA, 2023, 52 (03) : 411 - 420
  • [44] Cellular origins of testicular dysgenesis in rats exposed in utero to di(n-butyl) phthalate -: Discussion
    Toppari, J
    Mahood, K
    Loveland, K
    Andersson, AM
    Sharpe, R
    Rajpert-De Meyts, E
    Swan, S
    Mahood, K
    INTERNATIONAL JOURNAL OF ANDROLOGY, 2006, 29 (01): : 154 - 154
  • [45] Exposure to Di-2-Ethylhexyl Phthalate, Di-N-Butyl Phthalate and Bisphenol A through Infant Formulas
    Cirillo, Teresa
    Latini, Giuseppe
    Castaldi, Maria Antonietta
    Dipaola, Lucia
    Fasano, Evelina
    Esposito, Francesco
    Scognamiglio, Gelsomina
    Di Francesco, Fabio
    Cobellis, Luigi
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 63 (12) : 3303 - 3310
  • [46] Effect of di(n-butyl) phthalate on testicular oxidative damage and antioxidant enzymes in hyperthyroid rats
    Lee, Ena
    Ahn, Mee Young
    Kim, Hee Jin
    Kim, In Young
    Han, Soon Young
    Kang, Tae Seok
    Hong, Jin Hwan
    Park, Kui Lea
    Lee, Byung Mu
    Kim, Hyung Sik
    ENVIRONMENTAL TOXICOLOGY, 2007, 22 (03) : 245 - 255
  • [47] Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat
    Ahmad, Rahish
    Gautam, A. K.
    Verma, Y.
    Sedha, S.
    Kumar, Sunil
    ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH, 2014, 21 (04) : 3156 - 3165
  • [48] Effects of in utero di-butyl phthalate and butyl benzyl phthalate exposure on offspring development and male reproduction of rat
    Rahish Ahmad
    A. K. Gautam
    Y. Verma
    S. Sedha
    Sunil Kumar
    Environmental Science and Pollution Research, 2014, 21 : 3156 - 3165
  • [49] Neurochemical alterations following the exposure to di-n-butyl phthalate in rats
    Kassab, Rami B.
    Lokman, Maha S.
    Essawy, Ehab A.
    METABOLIC BRAIN DISEASE, 2019, 34 (01) : 235 - 244
  • [50] Neurochemical alterations following the exposure to di-n-butyl phthalate in rats
    Rami B. Kassab
    Maha S. Lokman
    Ehab A. Essawy
    Metabolic Brain Disease, 2019, 34 : 235 - 244
12345