Di(n-butyl) phthalate exposure impairs meiotic competence and development of mouse oocyte

被引：34
|
作者：
Li, Fei-Ping [1 ,2 ,3 ,4 ]
Zhou, Jie-Long [2 ]
Guo, Ai-Wei [2 ]
Liu, Yu [1 ,5 ]
Zhang, Fei [3 ,6 ]
Xu, Bai-Hui [1 ,3 ]
Liu, Rui [3 ,6 ]
Wang, Ya-Long [1 ,3 ]
Chen, Ming-Huang [3 ,6 ]
Lin, Yan-Hong [3 ,7 ]
He, Shu-Wen [1 ,3 ]
Liao, Bao-Qiong [1 ,3 ,8 ]
Fu, Xian-Pei [1 ,3 ]
Wang, Hai-Long [1 ,3 ]
机构：
[1] Xiamen Univ, Organ Transplantat Inst, Med Coll, Xiamen, Fujian, Peoples R China
[2] Southwest Forestry Univ, Coll Life Sci, Kunming, Yunnan, Peoples R China
[3] Fujian Key Lab Organ & Tissue Regenerat, Xiamen, Fujian, Peoples R China
[4] Sichuan Key Lab Conservat Biol Endangered Wildlif, Chengdu Res Base Giant Panda Breeding, Chengdu, Sichuan, Peoples R China
[5] Guangxi Univ, Med Coll, Nanning, Guangxi, Peoples R China
[6] Xiamen Univ, Zhongshan Hosp, Dept Gynaecol & Obstet, Xiamen, Fujian, Peoples R China
[7] Fujian Med Univ, Dept Gynecol, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China
[8] Xiamen Univ, Dept Gynaecol & Obstet, Dongfang Affiliated Hosp, Fuzhou, Fujian, Peoples R China
来源：
ENVIRONMENTAL POLLUTION | 2019年 / 246卷
基金：
中国国家自然科学基金;
关键词：
Mice oocyte; Meiosis; Dibutyl phthalate; Spindle; Cytoskeletons; CELL APOPTOSIS; CUMULUS CELLS; MATURATION; ESTERS; DISRUPTION; INDUCTION; QUALITY; TESTES;
D O I：
10.1016/j.envpol.2018.12.077
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Di(n-butyl) phthalate (DBP) is extensively used in industrial applications as plasticizer and stabilizer and its presence in the environment may present health risks for human. Previous studies have demonstrated its mutagenic, teratogenic, and carcinogenic ability. However, its effect on mammalian oocyte maturation remains unknown. In this study, we examined the effect of DBP on oocyte maturation both in vitro and in vivo. Our results showed that DBP could significantly reduce mice oocyte germinal vesicle breakdown (GVBD) and polar body extrusion (PBE) rates. In addition, oocyte cytoskeleton was damaged and cortical granule-free domains (CGFDs) were also disrupted. Finally, DBP induced early apoptosis of oocyte and granulosa cells (GCs). Collectively, these data demonstrate that DBP could reduce meiosis competence and mouse oocyte development. (C) 2018 Published by Elsevier Ltd.
引用
收藏
页码：597 / 607
页数：11
相关论文
共 50 条
  • [1] Neonatal exposure to di(N-butyl)phthalate alters male reproductive tract development.
    Kim, HS
    Han, SY
    Kim, TS
    Shin, JH
    Moon, HJ
    Kang, IH
    Kim, IY
    BIOLOGY OF REPRODUCTION, 2004, : 132 - 132
  • [2] Neonatal exposure to di(n-butyl) phthalate (DBP) alters male reproductive-tract development
    Kim, HS
    Kim, TS
    Shin, JH
    Moon, HJ
    Kang, IH
    Kim, IY
    Oh, JY
    Han, SY
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2004, 67 (23-24): : 2045 - 2060
  • [3] Quantitative evaluation of alternative mechanisms of blood disposition of di(n-butyl) phthalate and mono(n-butyl) phthalate in rats
    Keys, DA
    Wallace, DG
    Kepler, TB
    Conolly, RB
    TOXICOLOGICAL SCIENCES, 2000, 53 (02) : 173 - 184
  • [4] Diethylhexyl phthalate exposure impairs follicular development and affects oocyte maturation in the mouse
    Zhang, Xi-Feng
    Zhang, Lian-Jun
    Li, Lan
    Feng, Yan-Ni
    Chen, Bo
    Ma, Jin-Mei
    Huynh, Evanna
    Shi, Qing-Hua
    De Felici, Massimo
    Shen, Wei
    ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2013, 54 (05) : 354 - 361
  • [5] COMPARATIVE DEVELOPMENTAL TOXICITY OF N-BUTYL BENZYL PHTHALATE AND DI-N-BUTYL PHTHALATE IN RATS
    EMA, M
    KUROSAKA, R
    AMANO, H
    OGAWA, Y
    ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY, 1995, 28 (02) : 223 - 228
  • [6] Altered gene expression during rat Wolffian duct development following di(n-butyl) phthalate exposure
    Bowman, CJ
    Turner, KJ
    Sar, M
    Barlow, NJ
    Gaido, KW
    Foster, PMD
    TOXICOLOGICAL SCIENCES, 2005, 86 (01) : 161 - 174
  • [7] Effects of mono and di(n-butyl) phthalate on superoxide dismutase
    Prasanth, Ganesh K.
    Divya, L. M.
    Sadasivan, C.
    TOXICOLOGY, 2009, 262 (01) : 38 - 42
  • [8] In Utero Exposure to Di(n-butyl)phthalate Induces Morphological and Biochemical Changes in Rats Postpuberty
    Okayama, Yuya
    Wakui, Shin
    Wempe, Michael F.
    Sugiyama, Mitsuru
    Motohashi, Masaya
    Mutou, Tomoko
    Takahashi, Hiroyuki
    Kume, Eisuke
    Ikegami, Hiroshi
    TOXICOLOGIC PATHOLOGY, 2017, 45 (04) : 526 - 535
  • [9] Effects of in Utero Exposure to DI(n-Butyl) Phthalate on Development of Male Reproductive Tracts in Sprague-Dawley Rats
    Kim, Tae Sung
    Jung, Ki Kyung
    Kim, Soon Sun
    Kang, Il Hyun
    Baek, Jung Hee
    Nam, Hye-Seon
    Hong, Soon-Keun
    Lee, Byung Mu
    Hong, Jin Tae
    Oh, Ki Wan
    Kim, Hyung Sik
    Han, Soon Young
    Kang, Tae Seok
    JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2010, 73 (21-22): : 1544 - 1559
  • [10] n-Butyl hydrogen phthalate
    Parvez, M
    Sadiq-ur-Rahman
    Ali, S
    Mazhar, M
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2004, 60 : O151 - O152
12345