In vivo 1H NMR spectroscopy of individual human brain metabolites at moderate field strengths

被引:25
|
作者
Trabesinger, AH
Meier, D
Boesiger, P [1 ]
机构
[1] Swiss Fed Inst Technol, ETH, Inst Biomed Engn, Zurich, Switzerland
[2] Univ Zurich, CH-8006 Zurich, Switzerland
关键词
1H MRS; spectral editing; strong coupling; human brain;
D O I
10.1016/j.mri.2003.08.029
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This article reviews spectral editing techniques for in vivo H-1 NMR spectroscopy of human brain tissue at moderate field strengths of 1.5-3 Tesla. Various aspects of H-1 NMR spectroscopy are discussed with regard to in vivo applications. The parameter set [delta, J, n] (delta being the relative chemical shift, J the scalar coupling constant and n the number of coupled spins) is used to characterize the spin systems under investigation and to classify the editing techniques that are used in in vivo H-1 NMR spectroscopy. (C) 2003 Elsevier Inc. All rights reserved.
引用
收藏
页码:1295 / 1302
页数:8
相关论文
共 50 条
  • [21] Anomalous Dynamics of Labile Metabolites in Cold Human Blood Detected Using 1H NMR Spectroscopy
    Nagana Gowda, G. A.
    Pascua, Vadim
    Raftery, Daniel
    ANALYTICAL CHEMISTRY, 2023, 95 (34) : 12923 - 12930
  • [22] Detection of cerebral NAD+ by in vivo 1H NMR spectroscopy
    de Graaf, Robin A.
    Behar, Kevin L.
    NMR IN BIOMEDICINE, 2014, 27 (07) : 802 - 809
  • [23] Cluster Analysis Statistical Spectroscopy for the Identification of Metabolites in 1H NMR Metabolomics
    Heinzmann, Silke S.
    Waldenberger, Melanie
    Peters, Annette
    Schmitt-Kopplin, Philippe
    METABOLITES, 2022, 12 (10)
  • [24] Enhanced Neurochemical Profile of the Rat Brain Using In Vivo 1H NMR Spectroscopy at 16.4 T
    Hong, Sung-Tak
    Balla, David Zsolt
    Shajan, G.
    Choi, Changho
    Ugurbil, Kamil
    Pohmann, Rolf
    MAGNETIC RESONANCE IN MEDICINE, 2011, 65 (01) : 28 - 34
  • [25] Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy
    Tkác, I
    Rao, R
    Georgieff, MK
    Gruetter, R
    MAGNETIC RESONANCE IN MEDICINE, 2003, 50 (01) : 24 - 32
  • [26] 1H NMR spectroscopy of rat brain in vivo at 14.1 Tesla: Improvements in quantification of the neurochemical profile
    Mlynarik, Vladimir
    Cudalbu, Cristina
    Xin, Lijing
    Gruetter, Rolf
    JOURNAL OF MAGNETIC RESONANCE, 2008, 194 (02) : 163 - 168
  • [27] Determination of Regional Variations and Reproducibility in In Vivo 1H NMR Spectroscopy of the Rat Brain at 16.4 T
    Hong, Sung-Tak
    Balla, David Z.
    Pohmann, Rolf
    MAGNETIC RESONANCE IN MEDICINE, 2011, 66 (01) : 11 - 17
  • [28] Validation of 1H NMR spectroscopy as an analytical tool for methylamine metabolites in urine
    Lee, MB
    Storer, MK
    Blunt, JW
    Lever, M
    CLINICA CHIMICA ACTA, 2006, 365 (1-2) : 264 - 269
  • [29] 1H NMR study of monocrotaline and its metabolites in human blood
    Yang, Yi-Cheng
    Crowder, John
    Wardle, Nicholas J.
    Yang, Li
    White, Kenneth N.
    Wang, Zheng-Tao
    Bligh, S. W. Annie
    FOOD AND CHEMICAL TOXICOLOGY, 2011, 49 (11) : 2793 - 2799
  • [30] Picoliter 1H NMR spectroscopy
    Minard, KR
    Wind, RA
    JOURNAL OF MAGNETIC RESONANCE, 2002, 154 (02) : 336 - 343