Perimidine derivatives, 3(a-m), were synthesized in high yield (65-80%) using a microwave assisted cyclocondensation reaction of 1,8-diaminonaphthalene and carboxylic acid under acidic condition. Products were recrystallized from water or a mixture of water and ethanol. The synthesis of perimidine derivatives under microwave irradiation results in high yield and requires shorter time than by conventional heating method.