Solid-phase synthesis of peptide-derived enantiospecific nucleic acid analogs

被引：8

作者：

Shah, VJ

Cerpa, R

Kuntz, ID

Kenyon, GL

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,GRAD GRP BIOPHYS,SAN FRANCISCO,CA 94143

来源：

BIOORGANIC CHEMISTRY | 1996年 / 24卷 / 02期

关键词：

D O I：

10.1006/bioo.1996.0018

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N-9-adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (T-m) data obtained by hybridization experiments demonstrated that these PDNAs can anneal to their complementary nucleic acid strand dT(10). (C) 1996 Academic Press, Inc.

引用

页码：201 / 206

页数：6

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