On the analysis of complex biological supply chains: From process systems engineering to quantitative systems pharmacology

被引：4

作者：

Rao, Rohit T. ^{[1
]}

Scherholz, Megerle L. ^{[1
]}

Hartmanshenn, Clara ^{[1
]}

Bae, Seul-A ^{[1
]}

Androulakis, Ioannis P. ^{[1
,2
]}

机构：

[1] Rutgers State Univ, Dept Chem & Biochem Engn, 98 Brett Rd, Piscataway, NJ 08854 USA

[2] Rutgers State Univ, Dept Biomed Engn, 599 Taylor Rd, Piscataway, NJ 08854 USA

来源：

COMPUTERS & CHEMICAL ENGINEERING | 2017年 / 107卷

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Pharmacokinetics; Pharmacodynamics; Multi-scale systems biology; Quantitative systems pharmacology; CIRCADIAN-RHYTHMS; DRUG DISCOVERY; PHYSIOLOGICAL VARIABILITY; METABOLIC SYNDROME; CHRONIC DISEASE; INFLAMMATION; MODEL; SIMULATION; MECHANISM; CANCER;

D O I：

10.1016/j.compchemeng.2017.06.003

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

The use of models in biology has become particularly relevant as it enables investigators to develop a mechanistic framework for understanding the operating principles of living systems as well as in quantitatively predicting their response to both pathological perturbations and pharmacological interventions. This application has resulted in a synergistic convergence of systems biology and pharmacokinetic-pharmacodynamic modeling techniques that has led to the emergence of quantitative systems pharmacology (QSP). In this review, we discuss how the foundational principles of chemical process systems engineering inform the progressive development of more physiologically-based systems biology models. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：100 / 110

页数：11

共 50 条

[31] Quantitative Systems Pharmacology: A Framework for Context
Androulakis I.P.
Current Pharmacology Reports, 2016, 2 (3) : 152 - 160
[32] A Quantitative Systems Pharmacology Model of Asthma
Smirnov, Sergey
Lebedeva, Galina
Demin, Oleg
Petukhova, Tatiana
Cucurull-Sanchez, Lourdes
Fairman, David
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2017, 44 : S108 - S109
[33] QSP Designer: Quantitative systems pharmacology modeling with modular biological process map notation and multiple language code generation
Matthews, Richard J.
Hollinshead, David
Morrison, Daniel
van Der Graaf, Piet H.
Kierzek, Andrzej M.
CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY, 2023, 12 (07): : 889 - 903
[34] Moving towards quantitative and systems pharmacology
不详
NATURE REVIEWS DRUG DISCOVERY, 2011, 10 (12) : 889 - 889
[35] On the Systems Engineering Process of some Systems (of Systems)
Simo, Freddy Kamdem
Lenne, Dominique
2018 13TH ANNUAL CONFERENCE ON SYSTEM OF SYSTEMS ENGINEERING (SOSE), 2018, : 425 - 430
[36] New quantitative "reading" of dielectric spectra of complex biological systems
Nigmatullin, R. R.
Nelson, S. O.
IEEE TRANSACTIONS ON DIELECTRICS AND ELECTRICAL INSULATION, 2006, 13 (06) : 1325 - 1334
[37] Systems & Supply Chains for Circular Textiles
Le, Kilara
AATCC REVIEW, 2023, 23 (03)
[38] Information Systems and Coordination in Supply Chains
Chandra, Manoj
Saharia, Aditya
PROCEEDINGS OF THE 46TH ANNUAL HAWAII INTERNATIONAL CONFERENCE ON SYSTEM SCIENCES, 2013, : 4146 - 4153
[39] Information systems integration in the supply chains
Fajfer, Pawel
Kolinski, Adam
E-MENTOR, 2012, (01): : 84 - 89
[40] Risk analysis of information systems by event process chains
Mock, Ralf
Corvo, Maurizio
INTERNATIONAL JOURNAL OF CRITICAL INFRASTRUCTURES, 2005, 1 (2-3) : 247 - 257

← 1 2 3 4 5 →