Ferrous iron modulates quinolinate-mediated [3H]MK-801 binding to rat brain synaptic membranes in the presence of glycine and spermidine

被引：20
|
作者：
St'astny, F
Hinoi, E
Ogita, K
Yoneda, Y
机构：
[1] Setsunan Univ, Fac Pharmaceut Sci, Dept Pharmacol, Osaka 5730101, Japan
[2] Acad Sci Czech Republic, Inst Physiol, Dept Mol Neurobiol, CZ-14220 Prague, Czech Republic
来源：
NEUROSCIENCE LETTERS | 1999年 / 262卷 / 02期
关键词：
quinolinate; glutamate; N-methyl-D-aspartate receptor; H-3]MK-801 binding; spermidine; ferrous iron; NR subunits;
D O I：
10.1016/S0304-3940(99)00061-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Quinolinic acid (QUIN) displaced binding of agonist and antagonist ligands for the N-methyl-D-aspartate (NMDA) receptor in rat brain synaptic membranes. Both QUIN and glutamic acid (GLU) potentiated binding of [H-3]dizocilpine (MK-801) in the presence of glycine (GLY) alone, whereas the potentiation by QUIN was in a bell-shaped fashion in contrast to that by GLU. However, further addition of spermidine (SPD) induced bell-shaped potentiation by GLU as well as QUIN. The potentiation by QUIN was markedly deteriorated by the further addition of FeCl2 irrespective of the presence of GLY and SPD added. These results suggest that QUIN may potentiate [H-3]MK-801 binding to the open NMDA channel in rat brain synaptic membranes through a mechanism different from that underlying the potentiation by GLU. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：105 / 108
页数：4
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