Psoriatic arthritis is a progressive and often destructive form of seronegative inflammatory arthritis that is associated with psoriasis. It can be difficult to diagnose because it can present in a number of different ways, often indistinguishable from noninflammatory arthropathies such as osteoarthritis as well as inflammatory arthritis such as gout. Severe arthritis may be observed in the absence of psoriasis, or mild arthritis may be seen in the presence of moderate-to-severe psoriasis. A high index of suspicion, screening of psoriasis patients, and close follow-up and evaluation with rheumatology often is needed to make the diagnosis. Early recognition of the disorder and timely therapy can prevent long-term complications, such as permanent joint destruction and disability. With the advent of biologic agents, we are better equipped to manage psoriatic arthritis today. Because dermatologists are on the front-line of psoriasis management, we are perfectly poised to identify and help improve care for patients who suffer from both psoriasis and psoriatic arthritis. (c) 2005 Elsevier Inc. All rights reserved.
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Kings Coll London, St Johns Inst Dermatol, London SE1 9RT, England
Guys & St Thomas NHS Fdn Trust, NIHR GSTT KCL Comprehens Biomed Res Ctr, London, EnglandKings Coll London, St Johns Inst Dermatol, London SE1 9RT, England
Villanova, Federica
Di Meglio, Paola
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MRC Natl Inst Med Res, Dept Mol Immunol, London, EnglandKings Coll London, St Johns Inst Dermatol, London SE1 9RT, England
Di Meglio, Paola
Nestle, Frank O.
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Kings Coll London, St Johns Inst Dermatol, London SE1 9RT, England
Guys & St Thomas NHS Fdn Trust, NIHR GSTT KCL Comprehens Biomed Res Ctr, London, EnglandKings Coll London, St Johns Inst Dermatol, London SE1 9RT, England
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Clin Res Ctr, New Brunswick, NJ 08901 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Clin Res Ctr, New Brunswick, NJ 08901 USA